Evidence map›Paper›PMID 34355566›Full record

ArticleJournal of medicinal chemistry2021

Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.

Jared T Hammill, Vitaliy M Sviripa, Liliia M Kril, Diana Ortiz, Corinne M Fargo, Ho Shin Kim, Yizhe Chen, Jonah Rector, Amy L Rice, Malgorzata A Domagalska and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  7. Metabolic Pathways ofPharmaceutics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Jared T HammillDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.ORCID 0000-0002-9463-0526
Vitaliy M SviripaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.ORCID 0000-0002-7272-373X
Liliia M KrilCenter for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.
Diana OrtizDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States.
Corinne M FargoDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States.
Ho Shin KimDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Yizhe ChenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Jonah RectorDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Amy L RiceDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.ORCID 0000-0001-7398-9022
Malgorzata A DomagalskaDepartment of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium.
Kristin L BegleyCenter for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0596, United States.
Chunming LiuLucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.
Vivek M RangnekarLucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0093, United States.
Jean-Claude DujardinDepartment of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat, 155, Antwerpen 2000, Belgium.
David S WattDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.
Scott M LandfearDepartment of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, United States.
R Kiplin GuyDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.ORCID 0000-0002-9638-2060
University of Kentucky · USOregon Health & Science University · USInstituut voor Tropische Geneeskunde · BE

Funding

UNDERSTANDING THE MOLECULAR BASIS OF EPIGENETIC TRANSCRIPTIONAL SILENCINGP20RR020171 · NCRR · UNIVERSITY OF KENTUCKY · PI PAUMI, CHRISTIAN M · 2004 to 2011
$16.5M
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR SpectrometerS10OD028690 · OD · UNIVERSITY OF KENTUCKY · PI GARNEAU-TSODIKOVA, SYLVIE · 2020 to 2020
$1.4M
Development of Novel Therapeutics for LeishmaniasisR33AI127591 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI GUY, RODNEY KIPLIN, LANDFEAR, SCOTT M · 2019 to 2021
$1.4M
NCRR NIH HHS P20 RR020171NIAID NIH HHS R33 AI127591NIH HHS S10 OD028690
6 · The paper itself

Abstract

Leishmaniasis, a disease caused by protozoa of the

Indexed as

AnimalsFemaleLeishmaniaLeishmaniasis, CutaneousMiceMice, Inbred BALB CMicrosomes, LiverMolecular StructureQuinolinesStructure-Activity RelationshipTrypanocidal AgentsQuinolinesTrypanocidal Agents

Identifiers

PMID34355566
PMCPMC8404201
OpenAlexW3189950376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.