Evidence map›Paper›PMID 34355515›Full record

ArticleChemMedChem2021

Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin.

Samer S Daher, Miseon Lee, Xiao Jin, Christiana N Teijaro, Steven E Wheeler, Marlene A Jacobson, Bettina Buttaro, Rodrigo B Andrade

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Samer S DaherDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Miseon LeeDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Xiao JinDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Christiana N TeijaroDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Steven E WheelerDepartment of Chemistry, University of Georgia, 140 Cedar Street, Athens, GA 30602, USA.
Marlene A JacobsonMoulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 N. Broad Street, Philadelphia, PA 19140, USA.
Bettina ButtaroDepartment of Microbiology and Immunology, School of Medicine, Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Rodrigo B AndradeDepartment of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, USA.
Temple University · USUniversity of Georgia · US

Funding

Synthesis and Evaluation of Narrow-Spectrum Antibiotics Targeting MRSAR01GM126221 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI VALENTINE, ANN M · 2018 to 2019
$762k
National Science Foundation Graduate Research Fellowship Program DEG-12262NIGMS NIH HHS R01 GM126221NSF CHE-1665407
6 · The paper itself

Abstract

There is an urgent need for new antibiotics to mitigate the existential threat posed by antibiotic resistance. Within the ketolide class, solithromycin has emerged as one of the most promising candidates for further development. Crystallographic studies of bacterial ribosomes and ribosomal subunits complexed with solithromycin have shed light on the nature of molecular interactions (π-stacking and H-bonding) between from the biaryl side-chain of the drug and key residues in the 50S ribosomal subunit. We have designed and synthesized a library of solithromycin analogs to study their structure-activity relationships (SAR) in tandem with new computational studies. The biological activity of each analog was evaluated in terms of ribosomal affinity (K

Indexed as

Anti-Bacterial AgentsDensity Functional TheoryDose-Response Relationship, DrugEscherichia coliMacrolidesMicrobial Sensitivity TestsModels, MolecularMolecular StructureStaphylococcus aureusStructure-Activity RelationshipTriazolesAnti-Bacterial AgentsMacrolidessolithromycinTriazolesclick chemistrydensity functional theorymacrolidesolithromycinπ-stacking

Identifiers

PMID34355515
PMCPMC8571068
OpenAlexW3191477320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.