ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2021
Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Review
- Response to letter to the editor.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects.Magnetic resonance in medicine · 2023Article
- Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins.NeuroImage · 2023Article
- Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeTo compare transcapillary wall water exchange, a putative marker of cerebral metabolic health, in brain T
methodsDynamic-contrast-enhanced 7T MRI data were obtained from 19 HC and 23 PMS participants. High-resolution pharmacokinetic parametric maps representing tissue microvascular and microstructural properties were created by shutter-speed (SS) paradigm modeling to obtain estimates of blood volume fraction (v
resultsHigh-resolution parametric maps were produced to visualize tissue classes and resolve individual WM lesions. Normal-appearing gray matter k
conclusionsTranscapillary water exchange is reduced in PMS NAGM compared to HC and is further reduced in PMS WM lesions, suggesting pathologically impaired brain metabolism. k
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.