Evidence map›Paper›PMID 34355356›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021

Apoptosis in the late replication phase of Bovine alphaherpesvirus 1 in experimentally infected calves.

Hanna Carolina Campos Ferreira, Elaine Nery de Araújo, Nívia Carolina Lopes Rosado, Juliana Lopes Rangel Fietto, Marcus Rebouças Santos, Lidiany Lopes Gomes, Laura Morais Nascimento Silva, Gustavo Costa Bressan, Gustavo Ferreira Martins, Srinand Sreevatsan and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Hanna Carolina Campos FerreiraLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Elaine Nery de AraújoLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Nívia Carolina Lopes RosadoLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Juliana Lopes Rangel FiettoDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Marcus Rebouças SantosLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Lidiany Lopes GomesLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Laura Morais Nascimento SilvaLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Gustavo Costa BressanDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Gustavo Ferreira MartinsDepartamento de Biologia Geral, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil.
Srinand SreevatsanCollege of Veterinary Medicine, Michigan State University, F130G Veterinary Medical Center, 784 Wilson RD, Room 784 Wilson Road, Room F130G, East Lansing, MI, 48824, USA.
Abelardo Silva-JúniorLaboratório de Imunobiológicos e Virologia Animal, Departamento de Veterinária, Universidade Federal de Viçosa, Av. Peter Henry Rolfs, s/n, Viçosa, MG, 36570-000, Brazil. abelardo.junior@ufv.br.ORCID http://orcid.org/0000-0002-9379-1686
Universidade Federal de Viçosa · BRMichigan State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine alphaherpesvirus 1 (BoHV-1) is a pathogen causing respiratory and reproductive clinical signs in cattle. Infected animals may develop rhinotracheitis, vulvovaginitis, balanoposthitis, and abortion. Viral latency is generally established in neuronal ganglia simultaneously to a decrease in both genes or genome expression and viral replication. Under stressful conditions, infection is reactivated leading to viral replication and the manifestation of clinical signs. In this study, we evaluated both viral reactivation and apoptosis in trigeminal ganglia cells as BoHV-1 progressed from the latent to the acute phase of infection after dexamethasone administration in experimentally infected calves. To test ganglia cell death as a consequence of BoHV-1 infection, we stained the BoHV-1 samples with TUNEL after the viral shedding by the calves. RT-qPCR of apoptotic genes was also performed, showing the upregulation of the caspase 8 gene in the trigeminal ganglia from cattle experimentally infected with BoHV-1. These results showed the occurrence of apoptosis in ganglion cells of calves infected by BoHV-1.

Indexed as

ApoptosisCattle DiseasesHerpesviridae InfectionsHerpesvirus 1, BovineAnimalsCattleVirus ActivationVirus LatencyVirus ReplicationAlphaherpesvirusApoptosisLatencyNeuronal ganglia

Identifiers

PMID34355356
PMCPMC8578482
OpenAlexW3192240413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.