Evidence map›Paper›PMID 34355294›Full record

ArticlePflugers Archiv : European journal of physiology2021

Endothelin receptors in renal interstitial cells do not contribute to the development of fibrosis during experimental kidney disease.

Thomas H Neder, Julia Schrankl, Michaela A A Fuchs, Katharina A E Broeker, Charlotte Wagner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thomas H NederInstitute of Physiology, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Julia SchranklInstitute of Physiology, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Michaela A A FuchsInstitute of Physiology, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Katharina A E BroekerInstitute of Physiology, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Charlotte WagnerInstitute of Physiology, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany. charlotte.wagner@ur.de.ORCID 0000-0003-2239-5392
University of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal interstitial fibrosis is characterized by the development of myofibroblasts, originating from resident renal and immigrating cells. Myofibroblast formation and extracellular matrix production during kidney damage are triggered by various factors. Among these, endothelins have been discussed as potential modulators of renal fibrosis. Utilizing mouse models of adenine nephropathy (AN) and unilateral ureter occlusion (UUO), this study aimed to investigate the contribution of endothelin signaling in stromal mesenchymal resident renal interstitial cells. We found in controls that adenine feeding and UUO caused marked upregulations of endothelin-1 (ET-1) gene expression in endothelial and in tubular cells and a strong upregulation of ET

Indexed as

AdenineAnimalsFibrosisGene DeletionGene Expression RegulationKidneyKidney DiseasesMiceReceptor, Endothelin AReceptor, Endothelin BRNA, MessengerUp-RegulationUreteral ObstructionAdenineReceptor, Endothelin AReceptor, Endothelin BRNA, MessengerAdenine-induced nephropathyEndothelin-1Endothelin receptorsKidney fibrosisUnilateral ureter occlusion

Identifiers

PMID34355294
PMCPMC8433107
OpenAlexW3191731230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.