Evidence map›Paper›PMID 34355240›Full record

ArticleBJS open2021

Major hepatectomy with combined vascular resection for perihilar cholangiocarcinoma.

T Sugiura, K Uesaka, Y Okamura, T Ito, Y Yamamoto, R Ashida, K Ohgi, S Otsuka, M Nakagawa, T Aramaki and 1 more

Abstract read
In one paragraph

Article in BJS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. Prognostic Impact of Diabetes Mellitus and Extended Hepatectomy on Perihilar Cholangiocarcinoma.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

T SugiuraDivision of Hepato-Biliary-Pancreatic Surgery.ORCID 0000-0001-7163-4084
K UesakaDivision of Hepato-Biliary-Pancreatic Surgery.
Y OkamuraDivision of Hepato-Biliary-Pancreatic Surgery.ORCID 0000-0003-3384-2709
T ItoDivision of Hepato-Biliary-Pancreatic Surgery.
Y YamamotoDivision of Hepato-Biliary-Pancreatic Surgery.ORCID 0000-0002-8740-8468
R AshidaDivision of Hepato-Biliary-Pancreatic Surgery.
K OhgiDivision of Hepato-Biliary-Pancreatic Surgery.ORCID 0000-0003-1647-1117
S OtsukaDivision of Hepato-Biliary-Pancreatic Surgery.
M NakagawaDivision of Plastic and Reconstructive Surgery.
T AramakiDivision of Diagnostic Radiology, Shizuoka Cancer Centre, Shizuoka, Japan.
K AsakuraDivision of Diagnostic Radiology, Shizuoka Cancer Centre, Shizuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatectomy with vascular resection (VR) for perihilar cholangiocarcinoma (PHCC) is a challenging procedure. However, only a few reports on this procedure have been published and its clinical significance has not been fully evaluated.

methodsPatients undergoing surgical resection for PHCC from 2002-2017 were studied. The surgical outcomes of VR and non-VR groups were compared.

resultsSome 238 patients were included. VR was performed in 85 patients. The resected vessels were hepatic artery alone (31 patients), portal vein alone (37 patients) or both (17 patients). The morbidity rates were almost the same in the VR (49.4 per cent) and non-VR (43.8 per cent) groups (P = 0.404). The mortality rates of VR (3.5 per cent) and non-VR (3.3 per cent) were also comparable (P > 0.999). The median survival time (MST) was 45 months in the non-VR group and 36 months in VR group (P = 0.124). Among patients in whom tumour involvement was suspected on preoperative imaging and whose carbohydrate antigen 19-9 (CA19-9) value was 37 U/ml or less, MST in the VR group was significantly longer than that in the non-VR group (50 versus 34 months, P = 0.017). In contrast, when the CA19-9 value was greater than 37 U/ml, MST of the VR and non-VR groups was comparable (28 versus 29 months, P = 0.520).

conclusionHepatectomy with VR for PHCC can be performed in a highly specialized hepatobiliary centre with equivalent short- and long-term outcomes to hepatectomy without VR.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaKlatskin TumorBile Ducts, IntrahepaticHepatectomyHumans

Identifiers

PMID34355240
PMCPMC8342931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.