Evidence map›Paper›PMID 34355223›Full record

ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2018

Synthesizing Missing PET from MRI with Cycle-consistent Generative Adversarial Networks for Alzheimer's Disease Diagnosis.

Yongsheng Pan, Mingxia Liu, Chunfeng Lian, Tao Zhou, Yong Xia, Dinggang Shen

Open access · greenAbstract read
In one paragraph

Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
50.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Hybrid multi-modality multi-task learning for forecasting progression trajectories in subjective cognitive decline.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  8. Review
  9. Review
  10. A Cross-Modal Mutual Knowledge Distillation Framework for Alzheimer's Disease Diagnosis: Addressing Incomplete Modalities.IEEE transactions on automation science and engineering : a publication of the IEEE Robotics and Automation Society · 2025
    Article
  11. Article
  12. Review
  13. Turning brain MRI into diagnostic PET:Medical image analysis · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yongsheng PanSchool of Computer Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Mingxia LiuDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Chunfeng LianDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Tao ZhouDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yong XiaSchool of Computer Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USNorthwestern Polytechnical University · CN

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Diagnosis of Alzheimer's Disease Using Dynamic High-Order Brain NetworksR01EB022880 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB022880
6 · The paper itself

Abstract

Multi-modal neuroimages (e.g., MRI and PET) have been widely used for diagnosis of brain diseases such as Alzheimer's disease (AD) by providing complementary information. However, in practice, it is unavoidable to have missing data, i.e., missing PET data for many subjects in the ADNI dataset. A straightforward strategy to tackle this challenge is to simply discard subjects with missing PET, but this will significantly reduce the number of training subjects for learning reliable diagnostic models. On the other hand, since different modalities (i.e., MRI and PET) were acquired from the same subject, there often exist underlying relevance between different modalities. Accordingly, we propose a two-stage deep learning framework for AD diagnosis using both MRI and PET data. Specifically, in the

Identifiers

PMID34355223
PMCPMC8336606
OpenAlexW2891669248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.