ArticleHGG advances2021
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
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Article in HGG advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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20citing papers in PubMed, 3 pooled it
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of rs401681 (C > T) and rs402710 (C > T) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.Human molecular genetics · 2023Pooled it
- Cumulative Evidence for Relationships Between Multiple Variants in the TERT and CLPTM1L Region and Risk of Cancer and Non-Cancer Disease.Frontiers in oncology · 2022Pooled it
- Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease.bioRxiv : the preprint server for biology · 2026Article
- Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus.medRxiv : the preprint server for health sciences · 2026Article
- Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies.Biomedicines · 2025Review
- Circulating chromatin reveals the effects of disease-associated variants on gene regulation.bioRxiv : the preprint server for biology · 2025Article
- Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level.British journal of cancer · 2025Article
- Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer.The world journal of men's health · 2025Article
- Telomeres and telomerase in mesothelioma: Pathophysiology, biomarkers and emerging therapeutic strategies (Review).International journal of oncology · 2025Review
- Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential.Nature communications · 2025Article
- Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer.Nature communications · 2025Article
- Genetic regulation ofmedRxiv : the preprint server for health sciences · 2024Article
- Using Genetics to Investigate Relationships between Phenotypes: Application to Endometrial Cancer.Genes · 2024Review
- Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.Journal of the National Cancer Institute · 2023Article
- Article
- A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan.International journal of molecular sciences · 2023Article
- Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.American journal of human genetics · 2022Article
- Relationship between Telomere Length,International journal of molecular sciences · 2022Article
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Authors and funding
78 authors.
Hongjie ChenDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Arunabha MajumdarDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Lu WangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
Siddhartha KarMedical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Helian FengDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Douglas EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kyriaki MichailidouBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Jacques SimardDepartment of Molecular Medicine, Faculty of Medicine, Université Laval and Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Breast Cancer Association Consortium (BCAC)
Timothy BishopLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Iona C ChengDepartment of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA.
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephanie L SchmitGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Colorectal Transdisciplinary Study (CORECT)
Colon Cancer Family Registry Study (CCFR)
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Endometrial Cancer Association Consortium (ECAC)
Puya GharahkhaniStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Johannes SchumacherCenter for Human Genetics, University Hospital of Marburg, Marburg, Germany.
Janusz JankowskiCollege of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, UAE.
Ines GockelDepartment of Visceral, Transplant, Thoracic, and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Esophageal Cancer GWAS Consortium
Melissa L BondyDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, MN, USA.
Beatrice MelinDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Glioma International Case Control Consortium (GICC)
Corina LesseurDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andy R NessNational Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.
Brenda DiergaardeDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew F OlshanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Head-Neck Cancer GWAS Consortium
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
David C ChristianiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Maria T LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
James D McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
International Lung Cancer Consortium (ILCCO)
Myriam BrossardGenetic Epidemiology and Functional Genomics of Multifactorial Diseases Team, Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS-1124, Université Paris Descartes, Paris, France.
Mark M IlesLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.
Matthew H LawStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Stuart MacGregorStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Melanoma GWAS Consortium
Jonathan BeesleyDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Michelle R JonesCenter for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jonathan TyrerDepartment of Oncology, University of Cambridge, Cambridge, UK.
Stacey J WinhamDepartment of Health Science Research, Mayo Clinic, Rochester, MN, USA.
Ovarian Cancer Association Consortium (OCAC)
Alison P KleinDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gloria PetersenDepartment of Health Science Research, Mayo Clinic, Rochester, MN, USA.
Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brian M WolpinDepartment of Medical Oncology, Dana Farber Harvard Cancer Center, Boston, MA, USA.
Pancreatic Cancer Case-Control Consortium (PANC4)
Pancreatic Cancer Cohort Consortium (PanScan)
Rosalind A EelesOncogenetics Team, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Christopher A HaimanDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Zsofia Kote-JaraiOncogenetics Team, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Fredrick R SchumacherDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
PRACTICAL consortium
CRUK
BPC3
CAPS
PEGASUS
Paul BrennanNational Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Valerie GaborieauNational Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Renal Cancer GWAS Consortium
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbuaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Laufey T AmundadottirDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Peter KraftDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Bogdan PasaniucDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sara LindströmDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Funding
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MTropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MInternational Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0MGenome-Wide Association Study of Nonsynonymous SNPs in Colon CancerR01CA059045 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 1994 to 2011
$11.5MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MCancer Research UK 16561Cancer Research UK 19167NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA154823NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA244588NCI NIH HHS R03 CA123546NCI NIH HHS R21 CA182821NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA194393NCI NIH HHS U01 CA247283NCI NIH HHS U10 CA037429NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA148537NCI NIH HHS U19 CA203654NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NIEHS NIH HHS P30 ES010126World Health Organization 001
Abstract
Genome-wide association studies (GWASs) have identified thousands of cancer risk loci revealing many risk regions shared across multiple cancers. Characterizing the cross-cancer shared genetic basis can increase our understanding of global mechanisms of cancer development. In this study, we collected GWAS summary statistics based on up to 375,468 cancer cases and 530,521 controls for fourteen types of cancer, including breast (overall, estrogen receptor [ER]-positive, and ER-negative), colorectal, endometrial, esophageal, glioma, head/neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancer, to characterize the shared genetic basis of cancer risk. We identified thirteen pairs of cancers with statistically significant local genetic correlations across eight distinct genomic regions. Specifically, the 5p15.33 region, harboring the
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