Evidence map›Paper›PMID 34355184›Full record

ArticleRSC medicinal chemistry2021

Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy.

Sang-Yong Lee, Vigneshwaran Namasivayam, Nader M Boshta, Arianna Perotti, Salahuddin Mirza, Silvia Bua, Claudiu T Supuran, Christa E Müller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 4 countries.

Sang-Yong LeePharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.ORCID https://orcid.org/0000-0002-1165-0856
Vigneshwaran NamasivayamPharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.ORCID https://orcid.org/0000-0003-3031-3377
Nader M BoshtaPharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.ORCID https://orcid.org/0000-0002-4874-651X
Arianna PerottiPharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.
Salahuddin MirzaPharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.ORCID https://orcid.org/0000-0002-4944-8282
Silvia BuaDipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze Via Ugo Schiff 7,50019 Sesto Fiorentino Florence Italy.ORCID https://orcid.org/0000-0003-0107-2682
Claudiu T SupuranDipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze Via Ugo Schiff 7,50019 Sesto Fiorentino Florence Italy.ORCID https://orcid.org/0000-0003-4262-0323
Christa E MüllerPharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn An der Immenburg 4 D-53121 Bonn Germany christa.mueller@uni-bonn.de +49 228 73 2567 +49 228 73 2301.ORCID https://orcid.org/0000-0002-0013-6624
University of Bonn · DEFlorence (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) catalyzes the hydrolysis of extracellular nucleotides. It is expressed by immune cells and some carcinomas,

Identifiers

PMID34355184
PMCPMC8292979
OpenAlexW3166158858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.