Evidence map›Paper›PMID 34355174›Full record

ArticleNeuro-oncology advances

Preoperative imaging of glioblastoma patients using hyperpolarized

Jun Chen, Toral R Patel, Marco C Pinho, Changho Choi, Crystal E Harrison, Jeannie D Baxter, Kelley Derner, Salvador Pena, Jeff Liticker, Jaffar Raza and 9 more

Open access · goldAbstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  5. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  6. Genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA as noninvasive diagnostic markers for gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  7. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  8. Review
  9. Article
  10. Hyperpolarized [2-NeuroImage · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. DynamicMagnetic resonance in medicine · 2022
    Article
  15. Probing Cerebral Metabolism with HyperpolarizedACS chemical neuroscience · 2021
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Jun ChenAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Toral R PatelDepartment of Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Marco C PinhoDepartment of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Changho ChoiAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-7135-2447
Crystal E HarrisonAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jeannie D BaxterAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kelley DernerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Salvador PenaAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jeff LitickerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jaffar RazaDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Ronald G HallDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Galen D ReedGE Healthcare, Dallas, Texas, USA.
Chunyu CaiDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kimmo J HatanpaaDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
James A BanksonDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Robert M BachooDepartment of Neurosurgery and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Craig R MalloyAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bruce E MickeyDepartment of Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-7404-6971
Advanced Imaging Research (United States) · USThe University of Texas Southwestern Medical Center · USTexas Tech University · USBaylor Scott & White Health · USThe University of Texas at Dallas · USThe University of Texas MD Anderson Cancer Center · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
NIBIB NIH HHS P41 EB015908NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

backgroundGlioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells.

methodsThree patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3 T 1-2 days prior to tumor resection using a

resultsEach tumor was histologically confirmed to be a WHO grade IV glioblastoma with isocitrate dehydrogenase wild type. Total hyperpolarized

conclusionsPrior to surgical resection,

Indexed as

bicarbonateglioblastomahyperpolarizedpreoperativepyruvate

Identifiers

PMID34355174
PMCPMC8331053
OpenAlexW3177222955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.