ArticleNeuro-oncology advances
Predictors of survival in elderly patients undergoing surgery for glioblastoma.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Beyond Chronological Age: A Scoping Review of Neurosurgical Intervention for Central Nervous System Tumors in the Very Elderly.Current oncology (Toronto, Ont.) · 2026Article
- Prognostic Impact of Clinical Diagnosis-based Treatment in Glioblastoma Patients Aged ≥80 Years: A Single-center Cohort Study Focused on Performance Status Maintenance.Neurologia medico-chirurgica · 2026Article
- IL-32-mediated caspase-43 induction: Shaping macrophage differentiation & immunomodulation in glioblastoma multiforme.The Indian journal of medical research · 2025Article
- Evaluating treatment strategies and machine learning based treatment recommendation system for elderly patients with high grade gliomas.Frontiers in oncology · 2025Article
- The role of postoperative blood pressure management in early postoperative hemorrhage in awake craniotomy glioma patients.Neurosurgical review · 2024Article
- Glioblastoma in the oldest old: Clinical characteristics, therapy, and outcome in patients aged 80 years and older.Neuro-oncology practice · 2024Article
- Resection of positive tissue on methionine-PET is associated with improved survival in glioblastomas.Brain and behavior · 2023Article
- Prognostic Factors of Survival in Glioblastoma Multiforme Patients-A Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Optimal managements of elderly patients with glioblastoma.Japanese journal of clinical oncology · 2022Review
- Prognostic and Predictive Factors in Elderly Patients With Glioblastoma: A Single-Center Retrospective Study.Frontiers in aging neuroscience · 2021Article
- Real-world mortality and the effect of comorbidities on survival in glioblastoma: A database study using computed phenotypes for rapid, reliable patient identification.Neuro-oncology advancesArticle
- Optimizing management of the elderly patient with glioblastoma: Survival prediction online tool based on BC Cancer Registry real-world data.Neuro-oncology advancesArticle
- Impact of extent of surgical resection on survival in World Health Organization grade 4 gliomas: A molecular subtype-based analysis.Neuro-oncology advancesArticle
- Age is not enough: Clinical and therapeutic predictors of survival in elderly patients with de novo glioblastoma.Neuro-oncology advancesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlioblastoma (GBM) has a median age of diagnosis of 64 years old and the incidence increases with age. An increasing number of elderly patients are being diagnosed with GBM and undergoing surgery. These patients often present with multiple medical comorbidities and have significantly worse outcomes compared to adult patients. The goal of this study was to determine clinical predictors of survival in elderly patients undergoing surgery for GBM.
methodsOur brain tumor database was reviewed for all patients 65 years of age and older that underwent surgery for newly diagnosed GBM over a 14-year period from 2005 to 2018. Patient characteristics, comorbidities, complications, and treatment were collected. A total of 150 patients were included, and subdivided into two age categories; 65-74 years old and 75 years or older.
resultsThe median OS for all patients was 9.4 months. Neither the presence nor number of medical comorbidities were associated with decreased survival (
conclusionsThe presence of medical comorbidities is not a reason to exclude patients with GBM from surgical consideration. Excluding EOR and adjuvant treatment, postoperative complication is the most significant predictor of survival in elderly patients. Postoperative complications are associated with a longer LOS and are more common in patients 75 years of age and older.
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