Evidence map›Paper›PMID 34354924›Full record

ArticlePhotoacoustics2021

Ruiqing Ni, Alessia Villois, Xose Luis Dean-Ben, Zhenyue Chen, Markus Vaas, Stavros Stavrakis, Gloria Shi, Andrew deMello, Chongzhao Ran, Daniel Razansky and 2 more

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 57 citations in OpenAlex.

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  10. In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ruiqing NiInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Alessia VilloisInstitute for Chemical and Bioengineering, Department of Chemistry, ETH Zurich, Zurich, Switzerland.
Xose Luis Dean-BenInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Zhenyue ChenInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Markus VaasInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Stavros StavrakisInstitute for Chemical and Bioengineering, Department of Chemistry, ETH Zurich, Zurich, Switzerland.
Gloria ShiInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Andrew deMelloInstitute for Chemical and Bioengineering, Department of Chemistry, ETH Zurich, Zurich, Switzerland.
Chongzhao RanMartinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Daniel RazanskyInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
Paolo ArosioInstitute for Chemical and Bioengineering, Department of Chemistry, ETH Zurich, Zurich, Switzerland.
Jan KlohsInstitute for Biomedical Engineering, ETH & University of Zurich, Zurich, Switzerland.
University of Zurich · CHETH Zurich · CHHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abnormal deposition of fibrillar beta-amyloid (Aβ) deposits in the brain is one of the major histopathological hallmarks of Alzheimer's disease (AD). Here, we characterized curcumin-derivative CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of brain Aβ deposits in the arcAβ mouse model of AD cerebral amyloidosis. CRANAD-2 showed a specific and quantitative detection of Aβ fibrils

Indexed as

Alzheimer’s diseaseAmyloid-betaAnimal modelFluorescence imagingMulti-spectral optoacoustic tomography

Identifiers

PMID34354924
PMCPMC8321919
OpenAlexW3184195529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.