Evidence map›Paper›PMID 34354850›Full record

ArticleACS catalysis2021

Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis.

Robert M Hohlman, Sean A Newmister, Jacob N Sanders, Yogan Khatri, Shasha Li, Nikki R Keramati, Andrew N Lowell, K N Houk, David H Sherman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Developing 3-(2-Isocyano-6-methylbenzyl)-1ACS infectious diseases · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Robert M HohlmanLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Sean A NewmisterLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Jacob N SandersDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California.
Yogan KhatriLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Shasha LiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Nikki R KeramatiLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Andrew N LowellLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California.
David H ShermanLife Sciences Institute, University of Michigan, Ann Arbor, Michigan.
University of Michigan · USUniversity of California, Los Angeles · US

Funding

Discovery and Characterization of Natural Product Systems-Research Supplement to Promote DiversityR35GM118101 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHERMAN, DAVID H · 2016 to 2025
$3.3M
Development of New Methods for Computational Enzyme DesignF32GM122218 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SANDERS, JACOB NATHAN · 2017 to 2019
$176k
NIGMS NIH HHS F32 GM122218NIGMS NIH HHS R35 GM118101
6 · The paper itself

Abstract

Hapalindoles and related compounds (ambiguines, fischerindoles, welwitindolinones) are a diverse class of indole alkaloid natural products. They are typically isolated from the Stigonemataceae order of cyanobacteria and possess a broad scope of biological activities. Recently the biosynthetic pathway for assembly of these metabolites has been elucidated. In order to generate the core ring system,

Indexed as

biocatalysisdiversificationFam prenyltransferasefischerindolehapalindoleStig cyclase

Identifiers

PMID34354850
PMCPMC8336604
OpenAlexW3146607517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.