Evidence map›Paper›PMID 34354714›Full record

ReviewFrontiers in immunology2021

CD8

Joseph S Dolina, Natalija Van Braeckel-Budimir, Graham D Thomas, Shahram Salek-Ardakani

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 318 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
318citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

318 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Journal for immunotherapy of cancer · 2026
    Article
  12. RNF149/RBM25/MYC/PD-L1 axis promotes CD8Cellular oncology (Dordrecht, Netherlands) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Programmed Cell Death Protein 1-Interleukin-2 Bispecific Agents for Cancer Therapy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  20. Article

258 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph S DolinaCancer Immunology Discovery, Pfizer, San Diego, CA, United States.
Natalija Van Braeckel-BudimirCancer Immunology Discovery, Pfizer, San Diego, CA, United States.
Graham D ThomasCancer Immunology Discovery, Pfizer, San Diego, CA, United States.
Shahram Salek-ArdakaniCancer Immunology Discovery, Pfizer, San Diego, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A paradigm shift in the understanding of the exhausted CD8

Indexed as

ImmunityAnimalsAntigensBiomarkersCD8-Positive T-LymphocytesDisease ManagementDisease SusceptibilityEpigenesis, GeneticHost-Pathogen InteractionsHumansImmune Checkpoint InhibitorsImmune Checkpoint ProteinsMolecular Targeted TherapyNeoplasmsOrgan SpecificitySingle-Cell AnalysisAntigensBiomarkersImmune Checkpoint InhibitorsImmune Checkpoint Proteinscancer immunotherapyco-stimulatory/inhibitory receptorsCXCR3PD-1/PD-L1stem-like CD8+ T cellsT cell exhaustionT cell traffickingtumor immunity

Identifiers

PMID34354714
PMCPMC8330547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.