ArticleFrontiers in behavioral neuroscience2021
Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations.
Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Chronic stress alters neurotransmitter co-expression and disrupts context discrimination in a sex-dependent manner.IBRO neuroscience reports · 2026Article
- N-Stearidonoylethanolamine Restores CA1 Synaptic Integrity and Reduces Astrocytic Reactivity After Mild Traumatic Brain Injury.International journal of molecular sciences · 2026Article
- Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat.Communications biology · 2024Article
- Integrating and fragmenting memories under stress and alcohol.Neurobiology of stress · 2024Article
- Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications.The European journal of neuroscience · 2024Review
- Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses.Journal of neuroendocrinology · 2023Review
- Neurocognitive effects of stress: a metaparadigm perspective.Molecular psychiatry · 2023Review
- The interaction between social hierarchy and depression/anxiety: Involvement of glutamatergic pyramidal neurons in the medial prefrontal cortex (mPFC).Neurobiology of stress · 2023Article
- Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release.International journal of molecular sciences · 2023Article
- Plasticity of synapses and reward circuit function in the genesis and treatment of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.Nature communications · 2022Article
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Authors and funding
3 authors.
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Abstract
Chronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hippocampal information coding are disrupted as the stress becomes chronic. To examine this, we compared the impact of acute and chronic stress on neural activity in the CA1 subregion of male mice subjected to a chronic immobilization stress (CIS) paradigm. We observed that following first exposure to stress (acute stress), the spatial information encoded in the hippocampus sharpened, and the neurons became increasingly tuned to the underlying theta oscillations in the local field potential (LFP). However, following repeated exposure to the same stress (chronic stress), spatial tuning was poorer and the power of both the slow-gamma (30-50 Hz) and fast-gamma (55-90 Hz) oscillations, which correlate with excitatory inputs into the region, decreased. These results support the idea that acute and chronic stress differentially affect neural computations carried out by hippocampal circuits and suggest that acute stress may improve cognitive processing.
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