Evidence map›Paper›PMID 34354556›Full record

ArticleAdvanced functional materials2020

A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays.

Hossein Derakhshandeh, Fariba Aghabaglou, Alec McCarthy, Azadeh Mostafavi, Chris Wiseman, Zack Bonick, Ian Ghanavati, Seth Harris, Craig Kreikemeier-Bower, Seyed Masoud Moosavi Basri and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
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  12. Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  15. Article
  16. Article
  17. Research Progress of Hydrogel Microneedles in Wound Management.ACS biomaterials science & engineering · 2024
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hossein DerakhshandehDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Fariba AghabaglouDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Alec McCarthyDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Azadeh MostafaviDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Chris WisemanDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Zack BonickDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Ian GhanavatiDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Seth HarrisVeterinary Diagnostic Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln Lincoln, NE 68583, USA.
Craig Kreikemeier-BowerInstitutional Animal Care Program, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Seyed Masoud Moosavi BasriDepartment of Biomedical Engineering, American University of Sharjah, Sharjah 26666, United Arab Emirates.
Jordan RosenbohmDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Ruiguo YangDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Pooria MostafaluDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA.
Dennis OrgillDivision of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ali TamayolDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI RAZAVI RIZI, MOHAMMAD · 2016 to 2025
$20.8M
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle lossR01AR073822 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI TAMAYOL, ALI · 2018 to 2022
$1.8M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
NIAMS NIH HHS R01 AR073822NIGMS NIH HHS P20 GM113126NIGMS NIH HHS R01 GM126831
6 · The paper itself

Abstract

Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound bed. The delivery of vascular endothelial growth factor (VEGF) through the miniaturized needle arrays demonstrates that, in addition to the selection of suitable therapeutics, the delivery method and their spatial distribution within the wound bed is equally important. Administration of VEGF to chronic dermal wounds of diabetic mice using the programmable platform shows a significant increase in wound closure, re-epithelialization, angiogenesis, and hair growth when compared to standard topical delivery of therapeutics.

Indexed as

3D-printed needlesactive drug deliverychronic woundssmart bandages

Identifiers

PMID34354556
PMCPMC8336080

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.