Evidence map›Paper›PMID 34354350›Full record

ArticleInternational journal of nanomedicine2021

Jingyi Zhu, Junxing Yang, Lingzhou Zhao, Pingping Zhao, Jiqin Yang, Jinhua Zhao, Wenjun Miao

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. International journal of nanomedicine · 2023
    Article
  6. Nanomaterial Probes for Nuclear Imaging.Nanomaterials (Basel, Switzerland) · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingyi Zhu *School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China.ORCID 0000-0003-4299-2899
Junxing Yang *College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Lingzhou Zhao *Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Pingping ZhaoSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China.
Jiqin YangDepartment of Nuclear Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People's Republic of China.
Jinhua ZhaoDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China.
Wenjun MiaoSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSmart theranostic nanosystems own a favorable potential to improve internalization within tumor while avoiding nonspecific interaction with normal tissues. However, development of this type of theranostic nanosystems is still a challenge.

methodsIn this study, we developed the iodine-131 (

resultsThe synthesized theranostic nanosystems exhibit favorable water solubility and stability. Every functional PEI can complex approximately 12.4 DOX, which could sustainably release of DOX following a pH-dependent manner. Remarkably, due to the surface modification of APAS, the constructed theranostic nanosystems own the capacity to achieve pH-responsive charge conversion and further lead to improved cellular uptake in cancer cells under slightly acidic condition. Above all, based on the coexistence of DOX and radioactive DISCUSSION: The developed smart nanohybrid system provides a novel strategy to improve the tumor theranostic efficiency and may be applied for different types of cancer.

Indexed as

NeoplasmsTomography, Emission-Computed, Single-PhotonCell Line, TumorChemoradiotherapyDoxorubicinHumansHydrogen-Ion ConcentrationIodine RadioisotopesPolyethylene GlycolsPolyethyleneimineDoxorubicinIodine-131Iodine RadioisotopesPolyethylene GlycolsPolyethyleneiminechemo/radiotherapydoxorubiciniodine-131pH-controlled cellular uptakepolyethylenimineSPECT imaging

Identifiers

PMID34354350
PMCPMC8331118

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.