Evidence map›Paper›PMID 34354246›Full record

ArticleNature structural & molecular biology2021

Cryo-EM structure of the human MT

Hiroyuki H Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Structural and Dynamics Insights into Melatonin Binding to MT1 Receptor.Chembiochem : a European journal of chemical biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024
    Article
  16. Article
  17. Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  18. Article
  19. Article
  20. Melatonin and Related Compounds as Antioxidants.Mini reviews in medicinal chemistry · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Hiroyuki H OkamotoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-4655-2498
Hirotake MiyauchiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. iaska@tohoku.ac.jp.ORCID 0000-0003-0805-4049
Francesco RaimondiLaboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy.
Hirokazu TsujimotoDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tsukasa KusakizakoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-6186-6647
Wataru ShihoyaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0003-4813-5740
Keitaro YamashitaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-5442-7582
Ryoji SunoDepartment of Medical Chemistry, Kansai Medical University, Hirakata, Japan.
Norimichi NomuraDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6330-2239
Takuya KobayashiDepartment of Medical Chemistry, Kansai Medical University, Hirakata, Japan.
So IwataDepartment of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomohiro NishizawaDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. t-2438@yokohama-cu.ac.jp.ORCID 0000-0001-7463-8398
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID 0000-0003-1813-7008
The University of Tokyo · JPKyoto University · JPKansai Medical University · JPMRC Laboratory of Molecular Biology · GBScuola Normale Superiore · ITTohoku University · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin receptors (MT

Indexed as

Cryoelectron MicroscopyGTP-Binding ProteinsHumansMelatoninMembrane ProteinsProtein Structure, QuaternaryReceptor, Melatonin, MT1Signal TransductionStructure-Activity RelationshipGTP-Binding ProteinsMelatoninMembrane ProteinsReceptor, Melatonin, MT1TMEM150A protein, human

Identifiers

PMID34354246
OpenAlexW3192501640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.