ArticleCommunications biology2021
Neocortical inhibitory interneuron subtypes are differentially attuned to synchrony- and rate-coded information.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Adaptive modeling and inference of higher-order coordination in neuronal assemblies: A dynamic greedy estimation approach.PLoS computational biology · 2024Article
- Adaptive modeling and inference of higher-order coordination in neuronal assemblies: a dynamic greedy estimation approach.bioRxiv : the preprint server for biology · 2023Article
- Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.Anesthesiology · 2023Article
- Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type.NeuroImage · 2022Article
- Breaking Down a Rhythm: Dissecting the Mechanisms Underlying Task-Related Neural Oscillations.Frontiers in neural circuits · 2022Review
- Patterned perturbation of inhibition can reveal the dynamical structure of neural processing.eLife · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons can carry information with both the synchrony and rate of their spikes. However, it is unknown whether distinct subtypes of neurons are more sensitive to information carried by synchrony versus rate, or vice versa. Here, we address this question using patterned optical stimulation in slices of somatosensory cortex from mouse lines labelling fast-spiking (FS) and regular-spiking (RS) interneurons. We used optical stimulation in layer 2/3 to encode a 1-bit signal using either the synchrony or rate of activity. We then examined the mutual information between this signal and the interneuron responses. We found that for a synchrony encoding, FS interneurons carried more information in the first five milliseconds, while both interneuron subtypes carried more information than excitatory neurons in later responses. For a rate encoding, we found that RS interneurons carried more information after several milliseconds. These data demonstrate that distinct interneuron subtypes in the neocortex have distinct sensitivities to synchrony versus rate codes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.