Evidence map›Paper›PMID 34354167›Full record

ArticleScientific reports2021

Understanding the impact of SNPs associated with autism spectrum disorder on biological pathways in the human fetal and adult cortex.

E Golovina, T Fadason, T J Lints, C Walker, M H Vickers, J M O'Sullivan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  15. Metabolomic Signatures of Autism Spectrum Disorder.Journal of personalized medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E GolovinaLiggins Institute, University of Auckland, Auckland, New Zealand.
T FadasonLiggins Institute, University of Auckland, Auckland, New Zealand.
T J LintsSchool of Medical Science, University of Auckland, Auckland, New Zealand.
C WalkerSchool of Population Health, University of Auckland, Auckland, New Zealand.
M H VickersLiggins Institute, University of Auckland, Auckland, New Zealand.
J M O'SullivanLiggins Institute, University of Auckland, Auckland, New Zealand. justin.osullivan@auckland.ac.nz.
Maurice Wilkins Centre · NZUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by significant and complex genetic etiology. GWAS studies have identified genetic variants associated with ASD, but the functional impacts of these variants remain unknown. Here, we integrated four distinct levels of biological information (GWAS, eQTL, spatial genome organization and protein-protein interactions) to identify potential regulatory impacts of ASD-associated SNPs (p < 5 × 10

Indexed as

AdultAutism Spectrum DisorderBrainCerebral CortexDatabases, GeneticFetusGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansNeurodevelopmental DisordersPolymorphism, Single NucleotideProtein Interaction MappingQuantitative Trait Loci

Identifiers

PMID34354167
PMCPMC8342620
OpenAlexW3191119799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.