ArticleScientific reports2021
Biological age in healthy elderly predicts aging-related diseases including dementia.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contribution of Biological Age-Predictive Biomarkers to Nutrition Research: A Systematic Review of the Current Evidence and Implications for Future Research and Clinical Practice.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Effect of aspirin on healthspan in community-dwelling older adults: the ASPirin in reducing events in the elderly study.Age and ageing · 2026Trial
- Article
- Telomere Length and Cognitive Function Among Middle-Aged and Older Participants From Communities Underrepresented in Aging Research: A Preliminary Study.Journal of aging and health · 2026Article
- The BHARAT study: a multi-modal, multi-omics investigation of aging signatures in the Indian population.Aging · 2026Observational
- Cross-sectional evaluation of cardiovascular biological age using point-of-care ultrasound.European heart journal. Digital health · 2026Article
- Accelerated metabolomic aging and its association with social determinants of health in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study.npj aging · 2026Article
- Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank.Stroke and vascular neurology · 2026Article
- A comparison of differential DNA methylation analysis methods for continuous outcomes: implications for epigenetic studies.Epigenomics · 2026Article
- Contributions of Biological Aging to Longitudinal Incidence and Dynamic Progression of Atrial Fibrillation: A Prospective Cohort Study.Reviews in cardiovascular medicine · 2026Article
- The age paradox in post-infectious sequelae: physiological reserve outweighs chronological age in Long COVID susceptibility.medRxiv : the preprint server for health sciences · 2026Article
- Migration Effects on Cognition: Protocol for the Aging in Kerala Americans Research Study.JMIR research protocols · 2026Article
- A transcriptome-based tool for assessing skin aging reveals the ameliorative effect of stem cell-derived extracellular vesicles on UVB-induced aging.BMC genomics · 2026Article
- Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients.Annals of medicine · 2025Article
- Association of biological age acceleration with mortality in adults with diabetes or prediabetes: a mediating role of physical activity.Aging clinical and experimental research · 2025Article
- Does the southern health disadvantage extend to accelerated biological aging: evidence from the health and retirement study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Observational
- Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease.Biomolecules · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Application of biological age as a measure of an individual´s health status offers new perspectives into extension of both lifespan and healthspan. While algorithms predicting mortality and most aging-related morbidities have been reported, the major shortcoming has been an inability to predict dementia. We present a community-based cohort study of 1930 participants with a mean age of 72 years and a follow-up period of over 7 years, using two variants of a phenotypic blood-based algorithm that either excludes (BioAge1) or includes (BioAge2) neurofilament light chain (NfL) as a neurodegenerative marker. BioAge1 and BioAge2 predict dementia equally well, as well as lifespan and healthspan. Each one-year increase in BioAge1/2 was associated with 11% elevated risk (HR 1.11; 95%CI 1.08-1.14) of mortality and 7% elevated risk (HR 1.07; 95%CI 1.05-1.09) of first morbidities. We additionally tested the association of microRNAs with age and identified 263 microRNAs significantly associated with biological and chronological age alike. Top differentially expressed microRNAs based on biological age had a higher significance level than those based on chronological age, suggesting that biological age captures aspects of aging signals at the epigenetic level. We conclude that accelerated biological age for a given age is a predictor of major age-related morbidity, including dementia, among healthy elderly.
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