Evidence map›Paper›PMID 34354132›Full record

ArticleScientific reports2021

Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema.

Rosana Banzato, Nathalia M Pinheiro, Clarice R Olivo, Fernanda R Santana, Fernanda D T Q S Lopes, Luciana C Caperuto, Niels O Câmara, Milton A Martins, Iolanda F L C Tibério, Marco Antônio M Prado and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Rosana BanzatoDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Nathalia M PinheiroDepartment of Bioscience, Federal University of São Paulo, Rua Silva Jardim, 136 - Vila Mathias, Santos, SP, Brazil.
Clarice R OlivoDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Fernanda R SantanaDepartment of Medicine Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil.
Fernanda D T Q S LopesDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Luciana C CaperutoDepartment of Biological Science, Universidade Federal de São Paulo, Diadema, Brazil.
Niels O CâmaraImmunology, Universidade de São Paulo, São Paulo, Brazil.
Milton A MartinsDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Iolanda F L C TibérioDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Marco Antônio M PradoMolecular Medicine Group, Robarts Research Institute, London, Canada.
Vânia F PradoMolecular Medicine Group, Robarts Research Institute, London, Canada.
Carla M PradoDepartments of Medicine, School of Medicine, Universidade de São Paulo, São Paulo, Brazil. carla.prado@unifesp.br.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetylcholine (ACh), the neurotransmitter of the cholinergic system, regulates inflammation in several diseases including pulmonary diseases. ACh is also involved in a non-neuronal mechanism that modulates the innate immune response. Because inflammation and release of pro-inflammatory cytokines are involved in pulmonary emphysema, we hypothesized that vesicular acetylcholine transport protein (VAChT) deficiency, which leads to reduction in ACh release, can modulate lung inflammation in an experimental model of emphysema. Mice with genetical reduced expression of VAChT (VAChT KD

Indexed as

AcetylcholineAnimalsBronchoalveolar Lavage FluidCytokinesDisease Models, AnimalEmphysemaInflammationLungMacrophagesMaleMiceNeutrophilsNF-kappa BPancreatic ElastasePneumoniaPulmonary EmphysemaAcetylcholineCytokinesNF-kappa BPancreatic ElastaseVesicular Acetylcholine Transport Proteins

Identifiers

PMID34354132
PMCPMC8342425
OpenAlexW3188676230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.