Evidence map›Paper›PMID 34354056›Full record

ArticleNature communications2021

Rhodaelectro-catalyzed access to chromones via formyl C-H activation towards peptide electro-labeling.

Maximilian Stangier, Antonis M Messinis, João C A Oliveira, Hao Yu, Lutz Ackermann

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maximilian StangierInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany.
Antonis M MessinisInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany.
João C A OliveiraInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany.ORCID 0000-0002-2990-0315
Hao YuInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany.
Lutz AckermannInstitute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Göttingen, Germany. Lutz.Ackermann@chemie.uni-goettingen.de.ORCID 0000-0001-7034-8772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromones represent a privileged scaffold in medicinal chemistry and are an omnipresent structural motif in natural products. Chemically encoded non-natural peptidomimetics feature improved stability towards enzymatic degradation, cell permeability and binding affinity, translating into a considerable impact on pharmaceutical industry. Herein, a strategy for the sustainable assembly of chromones via electro-formyl C-H activation is presented. The rational design of the rhodaelectro-catalysis is guided by detailed mechanistic insights and provides versatile access to tyrosine-based fluorogenic peptidomimetics.

Indexed as

BenzaldehydesBiomimeticsCatalysisChromonesElectrochemical TechniquesMolecular StructureOxidation-ReductionPeptidomimeticsBenzaldehydesChromonesPeptidomimetics

Identifiers

PMID34354056
PMCPMC8342597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.