Evidence map›Paper›PMID 34354024›Full record

ReviewJournal of neurosurgical anesthesiology2023

Frailty Assessment and Prehabilitation Before Complex Spine Surgery in Patients With Degenerative Spine Disease: A Narrative Review.

Basma Mohamed, Ramani Ramachandran, Ferenc Rabai, Catherine C Price, Adam Polifka, Daniel Hoh, Christoph N Seubert

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neurosurgical anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Dose-response relationship between enhanced recovery protocol adherence and outcomes in geriatric spine metastasis surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  5. Lumbar spine fusion in elderly patients: risk factors for failure in achieving favorable outcomes.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Basma MohamedDepartments of Anesthesiology.
Ramani RamachandranDepartments of Anesthesiology.
Ferenc RabaiDepartments of Anesthesiology.
Catherine C PriceDepartments of Anesthesiology.
Adam PolifkaNeurosurgery.
Daniel HohNeurosurgery.
Christoph N SeubertDepartments of Anesthesiology.
University of Florida Health · USFlorida College · US

Funding

Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related DementiasK07AG066813 · NIA · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2020 to 2024
$810k
Predictors of POCD in Older AdultsF32AG021363 · NIA · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2002 to 2003
$80k
NIA NIH HHS F32 AG021363NIA NIH HHS K07 AG066813
6 · The paper itself

Abstract

Degenerative spine disease increases in prevalence and may become debilitating as people age. Complex spine surgery may offer relief but becomes riskier with age. Efforts to lessen the physiological impact of surgery through minimally invasive techniques and enhanced recovery programs mitigate risk only after the decision for surgery. Frailty assessments outperform traditional tools of perioperative risk stratification. The extent of frailty predicts complications after spine surgery such as reoperation for infection and 30-day mortality, as well as elements of social cost such as hospital length of stay and discharge to an advanced care facility. Symptoms of spine disease overlap with phenotypic markers of frailty; therefore, different frailty assessment tools may perform differently in patients with degenerative spine disease. Beyond frailty, however, cognitive decline and psychosocial isolation may interact with frailty and affect achievable surgical outcomes. Prehabilitation, which has reduced perioperative risk in colorectal and cardiac surgery, may benefit potential complex spine surgery patients. Typical prehabilitation includes physical exercise, nutrition supplementation, and behavioral measures that may offer symptomatic relief even in the absence of surgery. Nonetheless, the data on the efficacy of prehabilitation for spine surgery remains sparse and barriers to prehabilitation are poorly defined. This narrative review concludes that a frailty assessment-potentially supplemented by an assessment of cognition and psychosocial resources-should be part of shared decision-making for patients considering complex spine surgery. Such an assessment may suffice to prompt interventions that form a prehabilitation program. Formal prehabilitation programs will require further study to better define their place in complex spine care.

Indexed as

FrailtySpinal DiseasesHumansPostoperative ComplicationsPreoperative CarePreoperative Exercise

Identifiers

PMID34354024
PMCPMC8816967
OpenAlexW3188175244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.