ArticleProceedings of the National Academy of Sciences of the United States of America2021
Interactions among diameter, myelination, and the Na/K pump affect axonal resilience to high-frequency spiking.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial KExperimental physiology · 2026Article
- Clec7a Drives Microglial Activation-Mediated Myelin Degradation in Sepsis-Associated Encephalopathy.Inflammation · 2026Article
- Biomimetic action-potential transmission via mechano-gated potassium channels assembled by quadruple hydrogen-bonded crown ethers.Science advances · 2026Article
- Spatiotemporal Dynamics of Lateral NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional Alterations in Parvalbumin-Positive Interneurons after Traumatic Brain Injury in Somatosensory Cortex of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Spatio-temporal dynamics of lateral NabioRxiv : the preprint server for biology · 2025Article
- Brachial radiculopathy with intact central nervous system imaging following carbon monoxide poisoning: A case report.Clinical neurophysiology practice · 2025Article
- Spike transmission failures in axons from cortical neuronsiScience · 2024Article
- The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions.Cognitive neurodynamics · 2024Article
- Spike transmission failures in axons from mouse cortical pyramidal neurons in vivo.bioRxiv : the preprint server for biology · 2024Article
- Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus.Frontiers in computational neuroscience · 2024Article
- The NaBiophysical reviews · 2023Review
- Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions.Current biology : CB · 2023Article
- Human Sinoatrial Node Pacemaker Activity: Role of the Slow Component of the Delayed Rectifier KInternational journal of molecular sciences · 2023Article
- Axonal tuning by GABANeural regeneration research · 2023Article
- Review
- Resilience of compound action potential peaks to high-frequency firing in the mouse optic nerve.Physiological reports · 2023Article
- Activity-Dependent Fluctuations in Interstitial [KMolecules (Basel, Switzerland) · 2023Review
- Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury.Acta neuropathologica communications · 2022Article
- Reply to Kotler et al.: Changing ion concentrations in conductance-based models.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Abstract
Axons reliably conduct action potentials between neurons and/or other targets. Axons have widely variable diameters and can be myelinated or unmyelinated. Although the effect of these factors on propagation speed is well studied, how they constrain axonal resilience to high-frequency spiking is incompletely understood. Maximal firing frequencies range from ∼1 Hz to >300 Hz across neurons, but the process by which Na/K pumps counteract Na
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