Evidence map›Paper›PMID 34353909›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The

Jean-Baptiste Luizet, Julie Raymond, Thais Lourdes Santos Lacerda, Emeline Barbieux, Stanimir Kambarev, Magali Bonici, Frédérique Lembo, Kévin Willemart, Jean-Paul Borg, Jean Celli and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. CueO Possesses Copper Detoxification Activity Linking Bacterial Virulence and Drug Resistance in Brucella.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Journal of medical microbiology · 2026
    Article
  5. Article
  6. A genome-wide CRISPR screen defines host determinants of earlybioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. TheInternational journal of molecular sciences · 2025
    Article
  12. Beyond survival to domination:Frontiers in microbiology · 2025
    Review
  13. ThemicroLife · 2025
    Review
  14. Article
  15. Review
  16. Antioxidants (Basel, Switzerland) · 2024
    Article
  17. Review
  18. Frontiers in cellular and infection microbiology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Jean-Baptiste LuizetLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France.
Julie RaymondLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France.
Thais Lourdes Santos LacerdaLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France.ORCID 0000-0003-4582-9915
Emeline BarbieuxDepartment of Biology, Research Unit in Microorganisms Biology, Namur Research Institute for Life Sciences, 5000 Namur, Belgium.ORCID 0000-0002-3263-0264
Stanimir KambarevPaul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164.
Magali BoniciLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France.
Frédérique LemboEquipe labellisée Ligue 'Cell Polarity, Cell Signaling and Cancer', Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Aix-Marseille Université, CNRS, INSERM, 13009 Marseille, France.
Kévin WillemartDepartment of Biology, Research Unit in Microorganisms Biology, Namur Research Institute for Life Sciences, 5000 Namur, Belgium.ORCID 0000-0003-2849-7947
Jean-Paul BorgEquipe labellisée Ligue 'Cell Polarity, Cell Signaling and Cancer', Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Aix-Marseille Université, CNRS, INSERM, 13009 Marseille, France.ORCID 0000-0001-8418-3382
Jean CelliPaul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164.ORCID 0000-0002-6793-1788
Francine C A GérardLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France.ORCID 0000-0001-9865-2864
Eric MurailleDepartment of Biology, Research Unit in Microorganisms Biology, Namur Research Institute for Life Sciences, 5000 Namur, Belgium.ORCID 0000-0003-1250-5228
Jean-Pierre GorvelCentre d'Immunologie de Marseille-Luminy, CNRS, INSERM, Aix-Marseille Université, 13009 Marseille, France.
Suzana P SalcedoLaboratory of Molecular Microbiology and Structural Biochemistry, CNRS UMR5086, Université de Lyon, 69367 Lyon, France; suzana.salcedo@ibcp.fr.ORCID 0000-0001-5149-7756
Université Claude Bernard Lyon 1 · FRCentre National de la Recherche Scientifique · FRUniversité Libre de Bruxelles · BEWashington State University · USUniversity of Namur · BE

Funding

Effectors of Brucella intracellular replicationR01AI129992 · NIAID · WASHINGTON STATE UNIVERSITY · PI CELLI, JEAN A · 2017 to 2021
$2.1M
ER-associated degradation (ERAD) in the Brucella intracellular cycleR21AI127830 · NIAID · WASHINGTON STATE UNIVERSITY · PI CELLI, JEAN A · 2017 to 2018
$420k
NIAID NIH HHS R01 AI129992NIAID NIH HHS R21 AI127830
6 · The paper itself

Abstract

Perturbation of the endoplasmic reticulum (ER), a central organelle of the cell, can have critical consequences for cellular homeostasis. An elaborate surveillance system known as ER quality control ensures that cells can respond and adapt to stress via the unfolded protein response (UPR) and that only correctly assembled proteins reach their destination. Interestingly, several bacterial pathogens hijack the ER to establish an infection. However, it remains poorly understood how bacterial pathogens exploit ER quality-control functions to complete their intracellular cycle.

Indexed as

AnimalsBacterial ProteinsBrucella abortusBrucellosisEndoplasmic ReticulumEndoplasmic Reticulum-Associated DegradationHeLa CellsHost-Pathogen InteractionsHumansMembrane ProteinsMiceMice, Inbred C57BLReceptors, Antigen, T-Cell, alpha-betaTranscription Factor CHOPType IV Secretion SystemsX-Box Binding Protein 1Bacterial ProteinsDDIT3 protein, humanHERPUD1 protein, humanMembrane ProteinsReceptors, Antigen, T-Cell, alpha-betaTranscription Factor CHOPType IV Secretion SystemsX-Box Binding Protein 1XBP1 protein, humanBrucellaERADHerptrafficking

Identifiers

PMID34353909
PMCPMC8364137
OpenAlexW3187951115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.