Evidence map›Paper›PMID 34353901›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.

Jesús García-Castillo, Francisca Alcaraz-Pérez, Elena Martínez-Balsalobre, Diana García-Moreno, Marlies P Rossmann, Miriam Fernández-Lajarín, Manuel Bernabé-García, Ana B Pérez-Oliva, Virginia C Rodríguez-Cortez, Clara Bueno and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Zebrafish: a convenient tool for myelopoiesis research.Cell regeneration (London, England) · 2023
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jesús García-CastilloGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.ORCID 0000-0002-7520-6746
Francisca Alcaraz-PérezGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.ORCID 0000-0003-1802-4943
Elena Martínez-BalsalobreGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.ORCID 0000-0003-3287-2228
Diana García-MorenoGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Marlies P RossmannDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-2056-6792
Miriam Fernández-LajarínGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Manuel Bernabé-GarcíaGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.ORCID 0000-0003-4334-0059
Ana B Pérez-OlivaInstituto Murciano de Investigación Biosanitaria-Arrixaca, 30120 Murcia, Spain.ORCID 0000-0002-2596-0871
Virginia C Rodríguez-CortezJosep Carreras Leukemia Research Institute, University of Barcelona, 08036 Barcelona, Spain.
Clara BuenoJosep Carreras Leukemia Research Institute, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-1442-6216
Isaac AdattoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Suneet AgarwalStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.
Pablo MenéndezJosep Carreras Leukemia Research Institute, University of Barcelona, 08036 Barcelona, Spain.
Leonard I ZonDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-0860-926X
Victoriano MuleroInstituto Murciano de Investigación Biosanitaria-Arrixaca, 30120 Murcia, Spain.ORCID 0000-0001-9527-0211
María L CayuelaGrupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain; marial.cayuela@carm.es.ORCID 0000-0002-2021-9822
Instituto de Salud Carlos III · ESBoston Children's Hospital · USInstitució Catalana de Recerca i Estudis Avançats · ESInstituto Murciano de Investigación Biosanitaria · ES

Funding

Stem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3M
Molecular Circuits in the Hematopoietic Stem Cell NicheRC2DK120535 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2020 to 2024
$8.2M
Systems Biology of Bone Marrow Failure and MDS for Precision MedicineRC2DK122533 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI FIGUEROA, MARIA EUGENIA, FLEMING, MARK D · 2019 to 2023
$6.4M
Transcriptional response to signaling during hematopoiesisR01HL144780 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ZON, LEONARD IRA · 2019 to 2022
$2.1M
NHLBI NIH HHS R01 HL144780NHLBI NIH HHS U01 HL134812NIDDK NIH HHS RC2 DK120535NIDDK NIH HHS RC2 DK122533
6 · The paper itself

Abstract

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that zebrafish telomerase RNA (

Indexed as

AnimalsAnimals, Genetically ModifiedBinding SitesCells, CulturedDyskeratosis CongenitaGene Expression RegulationHumansInduced Pluripotent Stem CellsLarvaMutationMyelopoiesisPromoter Regions, GeneticProtein DomainsRNARNA Polymerase IITelomeraseRNARNA Polymerase IITelomerasetelomerase RNAZebrafish Proteinsdyskeratosis congenitamyelopoiesistelomerase RNA componentzebrafish

Identifiers

PMID34353901
PMCPMC8364177
OpenAlexW3187583892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.