Evidence map›Paper›PMID 34353900›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The E3 ubiquitin ligase RNF186 and

Kishu Ranjan, Matija Hedl, Clara Abraham

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Insights of Endocytosis Signaling in Health and Disease.International journal of molecular sciences · 2023
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kishu RanjanDepartment of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520.ORCID 0000-0003-1256-181X
Matija HedlDepartment of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520.
Clara AbrahamDepartment of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06520 clara.abraham@yale.edu.
Yale University · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Functional outcomes of inflammatory bowel disease associated variantsR01DK099097 · NIDDK · YALE UNIVERSITY · PI CLARA ABRAHAM · 2013 to 2026
$7.0M
NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK099097
6 · The paper itself

Abstract

Balancing microbial-induced cytokines and microbial clearance is critical at mucosal sites such as the intestine. How the inflammatory bowel disease (IBD)-associated gene

Indexed as

CytokinesHumansImmunity, InnateInflammatory Bowel DiseasesIntestinesMacrophagesMyeloid CellsNF-kappa BNod2 Signaling Adaptor ProteinPolymorphism, Single NucleotideReceptor-Interacting Protein Serine-Threonine Kinase 2Receptors, Pattern RecognitionToll-Like Receptor 2Toll-Like Receptor 4UbiquitinationUbiquitin-Protein LigasesCytokinesNF-kappa BNOD2 protein, humanNod2 Signaling Adaptor ProteinReceptor-Interacting Protein Serine-Threonine Kinase 2Receptors, Pattern RecognitionRIPK2 protein, humanRNF186 protein, humanTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4Ubiquitin-Protein Ligasesinflammatory bowel diseaseinnate immunitymacrophageubiquitination

Identifiers

PMID34353900
PMCPMC8364215
OpenAlexW3191308685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.