Evidence map›Paper›PMID 34353899›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Heat But Not Mechanical Hypersensitivity Depends on Voltage-Gated Ca

Daniel M DuBreuil, Eduardo Javier Lopez Soto, Simon Daste, Remy Meir, Daniel Li, Brian Wainger, Alexander Fleischmann, Diane Lipscombe

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Channels (Austin, Tex.) · 2026
    Article
  2. Nociceptor-enriched CAPS1 isoform couples to CabioRxiv : the preprint server for biology · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. The N-type calcium channel rises from the ashes.The Journal of clinical investigation · 2025
    Article
  6. Regulatory Action of Calcium and Calcium Channels in Pain Pathways.International journal of biological sciences · 2025
    Review
  7. Peripheral CaeNeuro · 2024
    Article
  8. Peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  9. Interleukin-1α links peripheral CaScientific reports · 2024
    Article
  10. Article
  11. Interleukin-1α links peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Voltage-dependent CaPflugers Archiv : European journal of physiology · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel M DuBreuilCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.ORCID 0000-0001-6202-4049
Eduardo Javier Lopez SotoCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Simon DasteCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Remy MeirCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Daniel LiCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Brian WaingerDepartments of Neurology and Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.
Alexander FleischmannCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912.
Diane LipscombeCarney Institute for Brain Science and Department of Neuroscience, Brown University, Providence, Rhode Island 02912 Diane_Lipscombe@brown.edu.ORCID 0000-0002-7146-9119
Allen Institute for Brain Science · USHarvard University · US

Funding

Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.T32MH020068 · NIMH · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, SHEINBERG, DAVID L · 1999 to 2025
$7.6M
A Human Stem Cell-Derived Neuromuscular Junction Model for Amyotrophic Lateral SclerosisDP2NS106664 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WAINGER, BRIAN JASON · 2017 to 2017
$2.6M
Neuroscience Advanced Predoctoral Institutional Training GrantT32NS062443 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, MOORE, CHRISTOPHER I · 2008 to 2018
$1.8M
Abnormal Gene Splicing in Neuropathic PainR00NS116123 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI LOPEZ SOTO, EDUARDO JAVIER · 2022 to 2024
$734k
Abnormal gene splicing in neuropathic pain - SupplementK99NS116123 · NINDS · BROWN UNIVERSITY · PI LOPEZ SOTO, EDUARDO JAVIER · 2020 to 2021
$184k
The role of CaV3.2 T-type calcium channel-expressing sensory neurons in nociception and chronic painF31NS093818 · NINDS · BROWN UNIVERSITY · PI DUBREUIL, DANIEL M · 2015 to 2017
$72k
NIMH NIH HHS T32 MH020068NINDS NIH HHS DP2 NS106664NINDS NIH HHS F31 NS093818NINDS NIH HHS K99 NS116123NINDS NIH HHS R00 NS116123NINDS NIH HHS R01 NS055251NINDS NIH HHS T32 NS062443
6 · The paper itself

Abstract

Voltage-gated Ca

Indexed as

AnimalsCalciumCalcium Channels, N-TypeHot TemperatureHyperalgesiaMiceNeuronsNociceptionNociceptorsPhysical StimulationPresynaptic TerminalsSkinSpinal Cord Dorsal HornSynaptic TransmissionCacna1b protein, mouseCalciumCalcium Channels, N-Typecacna1bcalcium channelconotoxinhyperalgesianociceptorN-type calcium channels

Identifiers

PMID34353899
PMCPMC8425970
OpenAlexW3192990730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.