Evidence map›Paper›PMID 34353896›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis.

Chen Tian, Jeremiah D Paskus, Erin Fingleton, Katherine W Roche, Bruce E Herring

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Autism, youth suicide, and psychedelics: A review of the 21st century evidence.Journal of the Chinese Medical Association : JCMA · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Rho signaling promotes cell excitability and synaptic transmission.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Common Genetic Variants inGenetics research · 2025
    Article
  12. Article
  13. Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold.Cold Spring Harbor perspectives in biology · 2024
    Review
  14. Presynaptic Rac1 in the hippocampus selectively regulates working memory.bioRxiv : the preprint server for biology · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Protein 4.1N Plays a Cell Type-Specific Role in Hippocampal Glutamatergic Synapse Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chen TianSection of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089.
Jeremiah D PaskusReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Erin FingletonReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Katherine W RocheReceptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Bruce E HerringSection of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 bherring@usc.edu.
National Institutes of Health · USUniversity of Southern California · USNational Institute of Neurological Disorders and Stroke · US

Funding

Regulation of Neuroligins and Effects on Synapse Number and FunctionZIANS003140 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2014 to 2025
$20.5M
Uncovering the Role of TRIO in Synaptic Function and Autism Spectrum DisorderR01NS112480 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HERRING, BRUCE · 2019 to 2023
$1.8M
Kalirin-7's role in synaptic transmission, plasticity and learning and memoryR00MH103398 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HERRING, BRUCE · 2016 to 2018
$730k
NIMH NIH HHS R00 MH103398NINDS NIH HHS R01 NS112480
6 · The paper itself

Abstract

We recently identified an autism spectrum disorder/intellectual disability (ASD/ID)-related

Indexed as

MutationAnimalsAutism Spectrum DisorderCell Adhesion Molecules, NeuronalDendritic SpinesExcitatory Postsynaptic PotentialsFemaleHippocampusIntellectual DisabilityMaleNeurogenesisRatsRats, Sprague-DawleySynapsesCell Adhesion Molecules, Neuronalneuroligin 1AMPA Receptordendritic spineglutamatergic synapseneurodevelopmental disorderNMDA ReceptorRhoGEF

Identifiers

PMID34353896
PMCPMC8445058
OpenAlexW3189019108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.