ArticleBMJ open diabetes research & care2021
Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study.
Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Handgrip strength measurement protocols in individuals with Down syndrome: a systematic review and meta-regression.Annals of medicine · 2025Pooled it
- Unraveling the role of muscle mass and strength in predicting type 2 diabetes risk: a systematic review.Acta diabetologica · 2025Pooled it
- Article
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Diabetes care performance across Europe: a cascade of care approach accounting for population diversity in 10 countries.BMC public health · 2026Article
- Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank.BMC medicine · 2026Article
- Grip Strength Estimation Using Input Data From a Commodity Smartphone: Model Development and Validation Study.JMIR human factors · 2026Article
- The bidirectional relationship between diabetes and poor muscle function in older adults: data from two population-based studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Diabetes is associated with reduced grip strength: A cross-sectional study of medical check-up results in Japanese seniors.Journal of diabetes investigation · 2026Article
- Bidirectional association between sarcopenia and diabetic kidney disease: a prospective cohort study.BMC nephrology · 2026Article
- Association of triglyceride-glucose related indices with cardiovascular diseases in individuals with low handgrip strength: a prospective cohort study of UK biobank.BMC cardiovascular disorders · 2026Article
- Associations Between Handgrip Strength and Markers of Insulin Resistance and Inflammation in Childhood and Adolescence: A Systematic Review With Meta-Analysis.Translational sports medicine · 2026Review
- Associations of Handgrip Strength with Bone Health and Mental Health in Postmenopausal Women: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Physical performance outweighs grip strength in predicting diabetes risk: evidence from a prospective cohort study.Journal of translational medicine · 2025Article
- Association between relative muscle strength and cardiometabolic multimorbidity in middle-aged and older Chinese adults.Acta diabetologica · 2025Article
- Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?Reviews in endocrine & metabolic disorders · 2025Review
- Mediation of fasting blood glucose between relative muscle strength and hypertension: insights from two cohorts.Diabetology & metabolic syndrome · 2025Article
- Muscle-building interventions improve glucose metabolism in elderly type 2 diabetic patients with sarcopenic obesity.Nutrition & metabolism · 2025Article
- Grip strength, metabolic syndrome, and type 2 diabetes mellitus: a prospective study.Journal of diabetes and metabolic disorders · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
introductionGrip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors. RESEARCH DESIGN AND
methodsThis was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression.
resultsThe median follow-up was 5.3 years (IQR: 4.7-6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles.
conclusionsGrip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality.
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