Evidence map›Paper›PMID 34353869›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM.

Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong V Cheung and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Next-generation anti-DLL3 radiopharmaceuticals targeting high-grade neuroendocrine lung and prostate cancers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Engineered Antibodies as Cancer Radiotheranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Antibody Engineering for Nuclear Imaging and Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sai Kiran SharmaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Maya SuzukiDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Hong XuDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Joshua A KorsenDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Zachary SamuelsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Hongfen GuoDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Brandon NemiebokaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Alessandra PiersigilliTri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, and Rockefeller University, New York, New York.
Kimberly J EdwardsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York; lewisj2@mskcc.org cheungn@mskcc.org.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; lewisj2@mskcc.org cheungn@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Immuno-PET is a powerful tool to noninvasively characterize the in vivo biodistribution of engineered antibodies.

Indexed as

Antibodies, Monoclonal, HumanizedNeural Cell Adhesion Molecule L1AnimalsImmunoglobulin Fab FragmentsImmunoglobulin GMiceMice, NudeTissue DistributionAntibodies, Monoclonal, HumanizedImmunoglobulin Fab FragmentsImmunoglobulin GNeural Cell Adhesion Molecule L1afucosylated antibodyaglycosylated antibodyFab arm exchangeimmuno-PET

Identifiers

PMID34353869
PMCPMC8973293
OpenAlexW3191212791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.