Trial reportGut2022
Psyllium reduces inulin-induced colonic gas production in IBS: MRI and
Trial report in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Fibre on Intestinal Volume and Gas in Irritable Bowel Syndrome
Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)
Effect of Modified Cellulose on Colonic Fermentation of Inulin (COCOA2)
Effect of Pre-dosing With Methylcellulose or Psyllium on Colonic Fermentation of Inulin (COCOA3)
A Randomised Placebo Controlled Trial of Chronic Feeding of INuliN And Methylcellulose On Colonic fermentatioN
Dietary Fibre Supplementation to Delay Disease Progression in Early Prostate Cancer
Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Increasing gut short-chain fatty acids protects intestinal barrier function but does not spare muscle glycogen or impact aerobic performance.The Journal of physiology · 2026Trial
- Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.The Journal of nutrition · 2025Trial
- A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men.The British journal of nutrition · 2023Trial
- Detection of changes in regional colonic fermentation in response to supplementing a low FODMAP diet with dietary fibres by hydrogen concentrations, but not by luminal pH.Alimentary pharmacology & therapeutics · 2023Trial
- Pathophysiology-driven use of natural products in irritable bowel syndrome: a review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Dietary Fiber and Glucagon-Like Peptide-1 Receptor Agonists in Obesity Management: Converging Mechanisms, Interactions, and Strategies for Durable Weight Control.Advances in nutrition (Bethesda, Md.) · 2026Review
- Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging.Neurogastroenterology and motility · 2026Article
- Dietary Behaviors, Digestive Symptoms, and Neurovegetative Features in Disorders of Gut-Brain Interaction: A Cross-Sectional Clinical Study.Nutrients · 2026Article
- From Husks and Seeds to Health: an Inevitable Outcome Rather than a Fluke.Current nutrition reports · 2026Review
- Triacetin and a Mushroom Blend Restore Butyrate Production by IBS Microbiomes Ex Vivo, Thus Promoting Barrier Integrity.International journal of molecular sciences · 2025Article
- Structural and Functional Properties of Fiber From Psyllium (Plantago ovata) Husk: Current Knowledge and Strategies to Expand Its Application in Food and Beyond.Comprehensive reviews in food science and food safety · 2025Review
- Natural Products for the Treatment of Irritable Bowel Syndrome.Gastroenterology & hepatology · 2025Article
- Gut microbiota in irritable bowel syndrome: a narrative review of mechanisms and microbiome-based therapies.Frontiers in immunology · 2025Review
- The Effect of Copper Nanoparticles on Liver Metabolism Depends on the Type of Dietary Fiber.Nutrients · 2024Article
- Innovative concepts in diet therapies in disorders of gut-brain interaction.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.Microbiome · 2024Article
- Safety and Tolerability of Microbial Inulinase Supplementation in Healthy Adults: A Randomized, Placebo-Controlled Trial.Gastro hep advances · 2024Article
- Metabolic response of intestinal microbiota to guar gum consumption.Frontiers in nutrition · 2023Article
- How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?BMJ oncology · 2023Review
- Immunomodulatory effects of inulin and its intestinal metabolites.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHealth-promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with IBS, limiting their intake. Our aim was to test if coadministering psyllium with inulin would reduce gas production.
designA randomised, four-period, four-treatment, placebo-controlled, crossover trial in 19 patients with IBS. Subjects ingested a 500 mL test drink containing either inulin 20 g, psyllium 20 g, inulin 20 g+ psyllium 20 g or dextrose 20 g (placebo). Breath hydrogen was measured every 30 min with MRI scans hourly for 6 hours. Faecal samples from a subset of the patients with IBS were tested using an
resultsColonic gas rose steadily from 0 to 6 hours, with inulin causing the greatest rise, median (IQR) AUC
conclusionsPsyllium reduced inulin-related gas production in patients with IBS but does not directly inhibit fermentation. Whether coadministration with psyllium increases the tolerability of prebiotics in IBS warrants further study. TRIAL REGISTRATION NUMBER: NCT03265002.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.