ArticleJournal of neurology, neurosurgery, and psychiatry2022
Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort.
Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results.Nature medicine · 2024Trial
- Factors influencing accelerated progression in behavioral variant frontotemporal dementia.Journal of neurology · 2026Article
- The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Executive Function Deficits in Genetic Frontotemporal Dementia: Results From the GENFI Study.Neurology. Genetics · 2025Article
- Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials.Brain : a journal of neurology · 2023Article
- Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales.Journal of neurology · 2023Article
- Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited.JAMA psychiatry · 2022Article
- Preparing for the age of therapeutic trials in frontotemporal lobar degeneration.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Extending the phenotypic spectrum assessed by the CDR plus NACC FTLD in genetic frontotemporal dementia.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundTherapeutic trials are now underway in genetic forms of frontotemporal dementia (FTD) but clinical outcome measures are limited. The two most commonly used measures, the Clinical Dementia Rating (CDR)+National Alzheimer's Disease Coordinating Center (NACC) Frontotemporal Lobar Degeneration (FTLD) and the FTD Rating Scale (FRS), have yet to be compared in detail in the genetic forms of FTD.
methodsThe CDR+NACC FTLD and FRS were assessed cross-sectionally in 725 consecutively recruited participants from the Genetic FTD Initiative: 457 mutation carriers (77 microtubule-associated protein tau (
resultsCross-sectionally, the mean FRS score was lower in all genetic groups compared with controls:
conclusionsBoth the FRS and CDR+NACC FTLD measure disease severity in genetic FTD mutation carriers throughout the timeline of their disease, although the FRS may be preferable as an outcome measure. However, neither address a number of key symptoms in the FTD spectrum, for example, motor and neuropsychiatric deficits, which future scales will need to incorporate.
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