Evidence map›Paper›PMID 34353823›Full record

ArticleBMJ case reports2021

Successful treatment of central nervous system lymphoproliferative disorder in a kidney-pancreas and stem cell transplanted patient using intrathecal rituximab.

Maria Anastasiou, Anne-Claire Mamez, Stavroula Masouridi, Maria Isabel Vargas, Karine Hadaya, Kristof Egervari, Yves Chalandon

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maria AnastasiouOncology, Division Hematology, Hopitaux Universitaires de Geneve, Geneva, Switzerland maria.anastasiou@hcuge.ch.
Anne-Claire MamezOncology, Division Hematology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Stavroula MasouridiOncology, Division Hematology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Maria Isabel VargasNeuroradiology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Karine HadayaNephrology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Kristof EgervariService of Clinical Pathology, Department of Genetic Medicine, Laboratory and Pathology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Yves ChalandonOncology, Division Hematology, Hopitaux Universitaires de Geneve, Geneva, Switzerland.
Hôpital Beau-Séjour · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central nervous system lymphoproliferative disorder (CNS-PTLD) after organ transplant is a unique clinicopathological entity and is associated with poor survival rates. When the CNS is involved, intravenous rituximab might not be the treatment of choice, due to its poor CNS penetration. However, intrathecal (IT) administration of rituximab has shown to be safe and efficient in small studies and in case series. We report here the case of a patient with late development of CNS-PTLD after kidney-pancreas transplantation who achieved complete remission after surgical resection and four cycles of IT rituximab and we provide a review of the literature for this treatment option.

Indexed as

Lymphoproliferative DisordersAntibodies, Monoclonal, Murine-DerivedCentral Nervous SystemHumansKidneyPancreasRituximabStem CellsAntibodies, Monoclonal, Murine-DerivedRituximabCNS cancerhaematology (drugs and medicines)haematology (incl blood transfusion)malignant disease and immunosuppressionneuroimaging

Identifiers

PMID34353823
PMCPMC8344276
OpenAlexW3187835602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.