ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Lung protective ventilation based on donor size is associated with a lower risk of severe primary graft dysfunction after lung transplantation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Donor-size-normalized tidal volume and early peak airway pressure-derived pressure burden after lung transplantation: an exploratory single-center cohort study.Frontiers in medicine · 2026Article
- Lung Ischemia-Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand?Antioxidants (Basel, Switzerland) · 2025Review
- Review
- Lower tidal volume ventilation post-bilateral lung transplantation is associated with ventilator-free days.Acta anaesthesiologica Scandinavica · 2025Article
- Machine Learning for Predicting Pulmonary Graft Dysfunction After Double-Lung Transplantation: A Single-Center Study Using Donor, Recipient, and Intraoperative Variables.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Applied physiological principles in the management of a lung allograft to thoracic cavity size mismatch in severe emphysema.JHLT open · 2024Review
- Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers.World journal of transplantation · 2023Review
- Mechanical Power Density Predicts Prolonged Ventilation Following Double Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMechanical ventilation immediately after lung transplantation may impact the development of primary graft dysfunction (PGD), particularly in cases of donor-recipient size mismatch as ventilation is typically based on recipient rather than donor size.
methodsWe conducted a retrospective cohort study of adult bilateral lung transplant recipients at our center between January 2010 and January 2017. We defined donor-based lung protective ventilation (dLPV) as 6 to 8 ml/kg of donor ideal body weight and plateau pressure <30 cm H
resultsThe cohort included 373 recipients; 24 (6.4%) developed PGD grade 3 at 48 to 72 hours, and 213 (57.3%) received dLPV. Mean pTLC ratio was 1.04 ± 0.18. dLPV was associated with significantly lower risks of PGD grade 3 (OR = 0.44; 95% CI: 0.29-0.68, p < 0.001) and 1-year mortality (HR = 0.49; 95% CI: 0.29-0.8, p = 0.018). There was a significant association between pTLC ratio and the risk of PGD grade 3, but this was attenuated by the use of dLPV.
conclusionsdLPV is associated with decreased risk of PGD grade 3 at 48 to 72 hours and decreased 1-year mortality. Additionally, dLPV attenuates the association between pTLC and both PGD grade 3 and 1-year mortality. Donor-based ventilation strategies may help to mitigate the risk of PGD and other adverse outcomes associated with size mismatch after lung transplantation.
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