Evidence map›Paper›PMID 34353684›Full record

ArticleJournal of voice : official journal of the Voice Foundation2023

Functional Analysis of Injectable Substance Treatment on Surgically Injured Rabbit Vocal Folds.

Sarah Bouhabel, Scott Park, Ksenia Kolosova, Neda Latifi, Karen Kost, Nicole Y K Li-Jessen, Luc Mongeau

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of voice : official journal of the Voice Foundation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah BouhabelDepartment of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada. Electronic address: sarah.bouhabel@muhc.mcgill.ca.
Scott ParkDepartment of Mechanical Engineering, McGill University, Montreal, Quebec, Canada.
Ksenia KolosovaDepartment of Physics, McGill University, Montreal, Quebec, Canada.
Neda LatifiDepartment of Mechanical Engineering, McGill University, Montreal, Quebec, Canada.
Karen KostDepartment of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
Nicole Y K Li-JessenDepartment of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada; School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada.
Luc MongeauDepartment of Otolaryngology - Head and Neck Surgery, McGill University, Montreal, Quebec, Canada; Department of Mechanical Engineering, McGill University, Montreal, Quebec, Canada.
McGill University · CA

Funding

Fluid Structure Interactions Within the Human LarynxR01DC005788 · NIDCD · PURDUE UNIVERSITY WEST LAFAYETTE · PI MONGEAU, LUC · 2003 to 2018
$6.4M
Bioprintable composite materials and microfluidic tools for vocal fold restoration and repairR01DC018577 · NIDCD · MCGILL UNIVERSITY · PI MONGEAU, LUC · 2021 to 2025
$2.5M
NIDCD NIH HHS R01 DC005788NIDCD NIH HHS R01 DC018577
6 · The paper itself

Abstract

objectivesThe objective of this study was to evaluate the efficacy of immediate injection treatments of dexamethasone, hyaluronic acid (HA)/gelatin (Ge) hydrogel and glycol-chitosan solution on the phonatory function of rabbit larynges at 42 days after surgical injury of the vocal folds, piloting a novel ex vivo phonatory functional analysis protocol.

methodsA modified microflap procedure was performed on the left vocal fold of 12 rabbits to induce an acute injury. Animals were randomized into one of four treatment groups with 0.1 mL injections of dexamethasone, HA/Ge hydrogel, glycol-chitosan or saline as control. The left mid vocal fold lamina propria was injected immediately following injury. The right vocal fold served as an uninjured control. Larynges were harvested at Day 42 after injection, then were subjected to airflow-bench evaluation. Acoustic, aerodynamic and laryngeal high-speed videoendoscopy (HSV) analyses were performed. HSV segments of the vibrating vocal folds were rated by three expert laryngologists. Six parameters related to vocal fold vibratory characteristics were evaluated on a Likert scale.

resultsThe fundamental frequency, one possible surrogate of vocal fold stiffness and scarring, was lower in the dexamethasone and HA/Ge hydrogel treatment groups compared to that of the saline control (411.52±11.63 Hz). The lowest fundamental frequency value was observed in the dexamethasone group (348.79±14.99 Hz). Expert visual ratings of the HSV segments indicated an overall positive outcome in the dexamethasone treatment group, though the impacts were below statistical significance.

conclusionDexamethasone injections might be used as an adjunctive option for iatrogenic vocal fold scarring. An increased sample size, histological correlate, and experimental method improvements will be needed to confirm this finding. Results suggested a promising use of HSV and acoustic analysis techniques to identify and monitor post-surgical vocal fold repair and scarring, providing a useful tool for future studies of vocal fold scar treatments.

Indexed as

CicatrixVocal CordsAnimalsDexamethasoneHyaluronic AcidHydrogelsRabbitsWound HealingDexamethasoneHyaluronic AcidHydrogelsVocal fold scarring—Wound healing—Tissue engineering—Functional analysis—Injectable hydrogels

Identifiers

PMID34353684
PMCPMC8807745
OpenAlexW3192755960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.