Evidence map›Paper›PMID 34353320›Full record

ArticleBMC medicine2021

Adverse childhood experiences and child mental health: an electronic birth cohort study.

Emily Lowthian, Rebecca Anthony, Annette Evans, Rhian Daniel, Sara Long, Amrita Bandyopadhyay, Ann John, Mark A Bellis, Shantini Paranjothy

Open access · goldAbstract read
In one paragraph

Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Emily LowthianPopulation Data Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK. e.m.lowthian@swansea.ac.uk.ORCID 0000-0001-9362-0046
Rebecca AnthonyDECIPHer, 1 - 3 Museum Place, School of Social Sciences, Cardiff University, Cardiff, CF10 3BD, UK.
Annette EvansDivision of Population Medicine, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS, UK.
Rhian DanielDivision of Population Medicine, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS, UK.
Sara LongDECIPHer, 1 - 3 Museum Place, School of Social Sciences, Cardiff University, Cardiff, CF10 3BD, UK.
Amrita BandyopadhyayNational Centre for Population Health and Wellbeing Research, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.
Ann JohnPopulation Data Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.
Mark A BellisCollege of Human Sciences, Bangor University, Wrexham Technology Park, Bangor, LL13 7YP, UK.
Shantini ParanjothyUniversity of Aberdeen, Aberdeen Health Data Science Centre, Institute of Applied Health Sciences, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK.
Swansea University · GBCardiff University · GBUniversity Hospital of Wales · GBBangor University · GBUniversity of Aberdeen · GB

Funding

Medical Research Council MC_PC_17211Medical Research Council MR/K023233/1Medical Research Council MR/W014386/1
6 · The paper itself

Abstract

backgroundAdverse childhood experiences (ACEs) are negatively associated with a range of child health outcomes. In this study, we explored associations between five individual ACEs and child mental health diagnoses or symptoms. ACEs included living with someone who had an alcohol-related problem, common mental health disorder or serious mental illness, or experienced victimisation or death of a household member.

methodsWe analysed data from a population-level electronic cohort of children in Wales, UK, (N = 191,035) between the years of 1998 and 2012. We used Cox regression with discrete time-varying exposure variables to model time to child mental health diagnosis during the first 15 years of life. Child mental health diagnoses include five categories: (i) externalising symptoms (anti-social behaviour), (ii) internalising symptoms (stress, anxiety, depression), (iii) developmental delay (e.g. learning disability), (iv) other (e.g. eating disorder, personality disorders), and (v) any mental health diagnosis, which was created by combining externalising symptoms, internalising symptoms and other. Our analyses were adjusted for social deprivation and perinatal risk factors.

resultsThere were strong univariable associations between the five individual ACEs, sociodemographic and perinatal factors (e.g. gestational weight at birth) and an increased risk of child mental health diagnoses. After adjusting for sociodemographic and perinatal aspects, there was a remaining conditional increased risk of any child mental health diagnosis, associated with victimisation (conditional hazard ratio (cHR) 1.90, CI 95% 1.34-2.69), and living with an adult with a common mental health diagnosis (cHR 1.63, CI 95% 1.52-1.75). Coefficients of product terms between ACEs and deprivation were not statistically significant.

conclusionThe increased risk of child mental health diagnosis associated with victimisation, or exposure to common mental health diagnoses, and alcohol problems in the household supports the need for policy measures and intervention strategies for children and their families.

Indexed as

Adverse Childhood ExperiencesAdultAnxietyChildCohort StudiesElectronicsFemaleHumansInfant, NewbornMental HealthPregnancyAdministrative dataAdverse childhood experiencesCohortMental healthSurvival analysisWales

Identifiers

PMID34353320
PMCPMC8344166
OpenAlexW3173456456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.