Evidence map›Paper›PMID 34352725›Full record

ReviewCurrent opinion in cell biology2021

Cell-cell contact and signaling in the muscle stem cell niche.

Allison P Kann, Margaret Hung, Robert S Krauss

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Study on theInternational journal of molecular medicine · 2025
    Article
  7. Article
  8. Measurement of Myonuclear Accretion In Vitro and In Vivo.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. We need to talk-how muscle stem cells communicate.Frontiers in cell and developmental biology · 2024
    Review
  14. Imaging analysis for muscle stem cells and regeneration.Frontiers in cell and developmental biology · 2024
    Review
  15. The muscle stem cell niche at a glance.Journal of cell science · 2023
    Article
  16. Article
  17. Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration.International journal of molecular sciences · 2023
    Article
  18. Muscle stem cells get a new look: Dynamic cellular projections as sensors of the stem cell niche.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Allison P KannDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Margaret HungDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Robert S KraussDepartment of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: Robert.Krauss@mssm.edu.

Funding

Cadherin-Dependent Regulation of Satellite Cell FunctionR01AR070231 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAUSS, ROBERT S. · 2016 to 2025
$4.9M
Interdisciplinary Training in Systems and Developmental Biology and Birth DefectsT32HD075735 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG · 2013 to 2022
$1.8M
NIAMS NIH HHS R01 AR070231NICHD NIH HHS T32 HD075735
6 · The paper itself

Abstract

Muscle stem cells (also called satellite cells or SCs) rely on their local niche for regulatory signals during homeostasis and regeneration. While a number of cell types communicate indirectly through secreted factors, here we focus on the significance of direct contact between SCs and their neighbors. During quiescence, SCs reside under a basal lamina and receive quiescence-promoting signals from their adjacent skeletal myofibers. Upon injury, the composition of the niche changes substantially, enabling the formation of new contacts that mediate proliferation, self-renewal, and differentiation. In this review, we summarize the latest work in understanding cell-cell contact within the satellite cell niche and highlight areas of open questions for future studies.

Indexed as

Satellite Cells, Skeletal MuscleStem Cell NicheCell DifferentiationCell ProliferationMuscle, SkeletalSignal TransductionCadherinCell adhesionMuscle stem cellNotch pathwaySatellite cellSkeletal muscleStem cell niche

Identifiers

PMID34352725
PMCPMC8678169

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.