ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2021
Changes in Body Composition, Muscle Strength, and Fat Distribution Following Kidney Transplantation.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Exercise therapy for kidney transplant recipients: a systematic review and meta-analysis with a focus on exercise type.Clinical and experimental nephrology · 2026Pooled it
- Thresholds of handgrip strength for all-cause mortality in patients with chronic kidney disease: a secondary systematic review with dose-response meta-analysis.Renal failure · 2024Pooled it
- Kidney transplantation: a possible solution to obstructive sleep apnea in patients with end-stage kidney disease.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Diagnosis, prevalence, and outcomes of sarcopenia in kidney transplantation recipients: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- The Application and Efficacy Evaluation of Autologous Fat Transplantation in Antiaging of the Face: Systematic Review and Meta-Analysis.Journal of healthcare engineering · 2022Pooled it
- Muscle weakness, pain, and fatigue impair daily function in chronic kidney disease: a cross-sectional analysis from the I-RACE study.Renal failure · 2026Article
- From Continuous-Flow Mechanical Circulatory Support to Heart Transplantation: Hemodynamic, Immunometabolic, and Body Composition Determinants of Rehabilitation Outcomes.Journal of clinical medicine · 2026Review
- Vitamin D3 and Body Composition Association with Graft Function in Long-Term Kidney Transplant Recipients.International journal of molecular sciences · 2026Article
- Sarcopenia in Kidney Transplantation: Bridging Pathophysiology to Patient-Centered Care.Nutrients · 2026Review
- Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Association of Myosteatosis and of Graft Loss after Kidney Transplantation: An International Observational Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Changes in Body Composition Compartments After Kidney Transplantation: A One-Year Prospective Study.Journal of clinical medicine · 2025Article
- Pre- and Post-Kidney Transplant Abdominal Computed Tomography-Based Muscle Measurements and Post-KT Outcomes.Clinical transplantation · 2025Article
- Review
- Time for Change: A 3-Year Prospective Study on Mediterranean Diet Adherence and Body Composition in Kidney Transplant Recipients.Healthcare (Basel, Switzerland) · 2025Article
- The phase angle before transplantation can predict the status of low muscle mass after kidney transplantation.Clinical and experimental nephrology · 2024Article
- Dialysis Duration, Time Interaction, and Visceral Fat Accumulation: A 6-Year Posttransplantation Study.Clinical and experimental nephrology · 2024Article
- Sarcopenic obesity is associated with adverse outcomes after kidney transplantation: a retrospective cohort study.International urology and nephrology · 2024Article
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations.Endocrinology and metabolism (Seoul, Korea) · 2024Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
RATIONALE &
objectiveLow muscle mass relative to fat mass (relative sarcopenia) has been associated with mortality and disability but has not been examined after kidney transplantation. We studied how measures of body composition change after receipt of a kidney allograft. STUDY
designProspective longitudinal cohort study. SETTING &
participants60 kidney transplant recipients, aged 20-60 years, at the University of Pennsylvania. EXPOSURE: Kidney transplantation. OUTCOME: Dual-energy x-ray absorptiometry measures of fat mass index (FMI) and appendicular lean mass index (ALMI, representing muscle mass), computed tomography measures of muscle density (low density represents increased intramuscular adipose tissue), dynamometer measures of leg muscle strength, and physical activity. ALMI relative to FMI (ALM ANALYTICAL APPROACH: Measures expressed as age, sex, and race-specific z scores for transplant recipients were compared with 327 healthy controls. Regression models were used to identify correlates of change in outcome z scores and compare transplant recipients with controls.
resultsAt transplantation, ALMI, ALMI LIMITATIONS: Lack of muscle biopsies precluded assessment of muscle histology and metabolism.
conclusionsThe 2-year interval after kidney transplantation was characterized by gains in muscle mass and strength that were outpaced by gains in fat mass, resulting in persistent relative sarcopenia.
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Registered trials
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