Evidence map›Paper›PMID 34352242›Full record

ArticleBiochimica et biophysica acta. Biomembranes2021

Interactions of HIV gp41's membrane-proximal external region and transmembrane domain with phospholipid membranes from

Madeleine Sutherland, Byungsu Kwon, Mei Hong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The Role of Cholesterol in M2 Clustering and Viral Budding Explained.Journal of chemical theory and computation · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Madeleine SutherlandDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Byungsu KwonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mei HongDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: meihong@mit.edu.
Massachusetts Institute of Technology · US

Funding

Structures and lipid interactions of curvature-inducing membrane peptides by NMRR01GM066976 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HONG, MEI · 2003 to 2021
$4.8M
NIGMS NIH HHS R01 GM066976
6 · The paper itself

Abstract

HIV-1 entry into cells requires coordinated changes of the conformation and dynamics of both the fusion protein, gp41, and the lipids in the cell membrane and virus envelope. Commonly proposed features of membrane deformation during fusion include high membrane curvature, lipid disorder, and membrane surface dehydration. The virus envelope and target cell membrane contain a diverse set of phospholipids and cholesterol. To dissect how different lipids interact with gp41 to contribute to membrane fusion, here we use

Indexed as

Amino Acid SequenceHIV Envelope Protein gp41Magnetic Resonance SpectroscopyMembrane LipidsModels, MolecularPhospholipidsProteolipidsHIV Envelope Protein gp41Membrane LipidsPhospholipidsProteolipidsproteoliposomesCholesterolMembrane curvatureProtein dynamicsVirus-cell fusion

Identifiers

PMID34352242
PMCPMC8826538
OpenAlexW3187508134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.