Evidence map›Paper›PMID 34352226›Full record

ArticleCell reports2021

Systemic IL-15, IFN-γ, and IP-10/CXCL10 signature associated with effective immune response to SARS-CoV-2 in BNT162b2 mRNA vaccine recipients.

Cristina Bergamaschi, Evangelos Terpos, Margherita Rosati, Matthew Angel, Jenifer Bear, Dimitris Stellas, Sevasti Karaliota, Filia Apostolakou, Tina Bagratuni, Dimitris Patseas and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 3 syntheses or guidelines pooled it, 231 citations in OpenAlex.

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  16. Inflammatory mediators of mRNA vaccine-induced adverse reactions in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  17. Article
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  19. Host Responses to SARS-CoV-2 with an Emphasis on Cytokines.International journal of molecular sciences · 2026
    Review
  20. Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Cristina BergamaschiHuman Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens 11528, Greece.
Margherita RosatiHuman Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Matthew AngelVaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Center for Cancer Research Collaborative Bioinformatics Resource, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jenifer BearHuman Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Dimitris StellasHuman Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Sevasti KaraliotaHuman Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Filia ApostolakouDepartment of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens 11527, Greece.
Tina BagratuniDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens 11528, Greece.
Dimitris PatseasDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens 11528, Greece.
Sentiljana GumeniDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens 15784, Greece.
Ioannis P TrougakosDepartment of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens 15784, Greece.
Meletios A DimopoulosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens 11528, Greece.
Barbara K FelberHuman Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: barbara.felber@nih.gov.
George N PavlakisHuman Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: george.pavlakis@nih.gov.
National and Kapodistrian University of Athens · GRNational Cancer Institute · USCenter for Cancer Research · USChildren's Hospital Agia Sophia · GRFrederick National Laboratory for Cancer Research · US

Funding

COVID-19 vaccine in naive individuals and cancer patientsZIABC011940 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FELBER, BARBARA K · 2020 to 2024
$3.7M
COVID-19 vaccine developmentZIABC011939 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLAKIS, GEORGE N. · 2020 to 2022
$2.0M
6 · The paper itself

Abstract

Early responses to vaccination are important for shaping both humoral and cellular protective immunity. Dissecting innate vaccine signatures may predict immunogenicity to help optimize the efficacy of mRNA and other vaccine strategies. Here, we characterize the cytokine and chemokine responses to the 1

Indexed as

AdultAgedAntibodies, ViralBNT162 VaccineChemokine CXCL10COVID-19COVID-19 VaccinesFemaleHumansImmunityInterferon-gammaInterleukin-15MaleMiddle AgedRNA, MessengerSARS-CoV-2Antibodies, ViralBNT162 VaccineChemokine CXCL10COVID-19 VaccinesCXCL10 protein, humanIL15 protein, humanInterferon-gammaInterleukin-15RNA, MessengercytokinesIFN-γIL-15innate immunityIP10/CXCL10mRNA vaccineSARS-CoV-2Spike antibody

Identifiers

PMID34352226
PMCPMC8299183
OpenAlexW3186153681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.