Evidence map›Paper›PMID 34351641›Full record

ArticlePhotodermatology, photoimmunology & photomedicine2022

Effectiveness of narrowband UVB phototherapy and psoralen plus UVA photochemotherapy in the treatment of generalized lichen planus: Results from a large retrospective analysis and an update of the literature.

Benedikt Weber, Elias Marquart, Sonja Radakovic, Adrian Tanew

Open access · hybridAbstract read
In one paragraph

Article in Photodermatology, photoimmunology & photomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Lichen Planus: What is New in Diagnosis and Treatment?American journal of clinical dermatology · 2024
    Review
  5. Review
  6. Article
  7. Lichen Planus.Frontiers in medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benedikt WeberDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Elias MarquartDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Sonja RadakovicDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-6079-9713
Adrian TanewDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-4433-2790
Medical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this retrospective study was to compare the efficacy and safety of different phototherapeutic modalities in the treatment of cutaneous lichen planus (LP).

methodsWe retrospectively analyzed the chart data of 53 patients with generalized LP who had been subjected to narrowband UVB (NB-UVB) or photochemotherapy (PUVA) between January 1997 and April 2020. Of these, 30 patients had received NB-UVB, 18 patients oral PUVA and 5 patients bath PUVA.

resultsFifty patients completed a full treatment course. The percentage of patients with a complete (>90% clearing) or good (51%-90% clearing) response was similar for NB-UVB versus PUVA (86.2% vs. 90.5%; P = 1.00). The number of exposures required for obtaining a complete or good response was also comparable for both treatment groups (NB-UVB: 28.9 ± 12.3 vs. PUVA: 25.4 ± 10.1; P = .209). Adverse events, in particular gastrointestinal upsets, were recorded in 26.1% of patients treated with oral PUVA while none were observed with NB-UVB.

conclusionThe therapeutic outcome and the number of treatments required for achieving a complete or good response were comparable for NB-UVB and PUVA; however, PUVA therapy was associated with a substantially higher rate of moderate adverse events.

Indexed as

Lichen PlanusPhotochemotherapyUltraviolet TherapyFicusinHumansPhotosensitizing AgentsPhototherapyPUVA TherapyRetrospective StudiesTreatment OutcomeFicusinPhotosensitizing Agentseffectivenesslichen planusphotochemotherapyphototherapysafety

Identifiers

PMID34351641
PMCPMC9291473
OpenAlexW3187730352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.