Evidence map›Paper›PMID 34351578›Full record

ArticleBreast cancer (Tokyo, Japan)2022

Interactions between exposure to polycyclic aromatic hydrocarbons and xenobiotic metabolism genes, and risk of breast cancer.

Derrick G Lee, Johanna M Schuetz, Agnes S Lai, Igor Burstyn, Angela Brooks-Wilson, Kristan J Aronson, John J Spinelli

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Breast cancer (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. A Weibull mixture cure frailty model for high-dimensional covariates.Statistical methods in medical research · 2025
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Derrick G LeeCancer Control Research, BC Cancer, Vancouver, BC, Canada. dlee@stfx.ca.ORCID https://orcid.org/0000-0003-0079-8385
Johanna M SchuetzCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Agnes S LaiCancer Control Research, BC Cancer, Vancouver, BC, Canada.
Igor BurstynDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada.
Kristan J AronsonDepartment of Public Health Sciences, Queen's University, Kingston, ON, Canada.
John J SpinelliSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Canada's Michael Smith Genome Sciences Centre · CADrexel University · USQueen's University · CASimon Fraser University · CASt. Francis Xavier University · CAUniversity of British Columbia · CA

Funding

CIHR 69036
6 · The paper itself

Abstract

purposePolycyclic aromatic hydrocarbons (PAHs) are a group of environmental pollutants associated with multiple cancers, including female breast cancer. Several xenobiotic metabolism genes (XMGs), including the CYP450 family, play an important role in activating and detoxifying PAHs, and variations in the activity of the enzymes they encode can impact this process. This study aims to examine the association between XMGs and breast cancer, and to assess whether these variants modify the effects of PAH exposure on breast cancer risk.

methodsIn a case-control study in Vancouver, British Columbia, and Kingston, Ontario, 1037 breast cancer cases and 1046 controls had DNA extracted from blood or saliva and genotyped for 138 single nucleotide polymorphisms (SNPs) and tagSNPs in 27 candidate XMGs. Occupational PAH exposure was assessed using a measurement-based job-exposure matrix.

resultsAn association between genetic variants and breast cancer was observed among six XMGs, including increased risk among the minor allele carriers of AKR1C3 variant rs12387 (OR 2.71, 95% CI 1.42-5.19) and AKR1C4 variant rs381267 (OR 2.50, 95% CI 1.23-5.07). Heterogeneous effects of occupational PAH exposure were observed among carriers of AKR1C3/4 variants, as well as the PTGS2 variant rs5275.

conclusionOur findings support an association between SNPs of XMGs and female breast cancer, including novel genetic variants that modify the toxicity of PAH exposure. These results highlight the interplay between genetic and environmental factors, which can be helpful in understanding the modifiable risks of breast cancer and its complex etiology.

Indexed as

Gene-Environment InteractionAdultAgedAged, 80 and overAldo-Keto Reductase Family 1 Member C3Breast NeoplasmsCanadaCase-Control StudiesCyclooxygenase 2FemaleHeterozygoteHumansMiddle AgedOccupational ExposureOxidoreductasesPolycyclic Aromatic HydrocarbonsAKR1C3 protein, humanAldo-Keto Reductase Family 1 Member C3Cyclooxygenase 2OxidoreductasesPolycyclic Aromatic HydrocarbonsPTGS2 protein, humantrans-1,2-dihydrobenzene-1,2-diol dehydrogenaseXenobioticsBreast cancerCYP450Effect modificationGene–environment interactionMetabolismOccupational exposurePolycyclic aromatic hydrocarbons

Identifiers

PMID34351578
OpenAlexW3193120325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.