SynthesisBrain imaging and behavior2022
Functional alterations of the suicidal brain: a coordinate-based meta-analysis of functional imaging studies.
Synthesis in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt.Frontiers in psychiatry · 2026Pooled it
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Brain structural-functional connectivity coupling and glucose metabolism in adolescents with bipolar disorder and major depressive disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Neural Representations of Death-Related Concepts Identify Conceptual Alteration of Self in Suicidal Youth.Human brain mapping · 2026Article
- Electroconvulsive therapy modulates Fronto-temporal functional connectivity in adolescents with depression and suicidal ideation.Frontiers in neuroimaging · 2026Article
- Advancing Research on Suicide and Mental Health in Autistic Adults Through a Research Domain Criteria (RDoC)-Inspired Framework.Autism in adulthood · 2025Article
- Genetic approach uncovering the pathways between childhood maltreatment and suicide attempt.Molecular psychiatry · 2025Article
- Differential neural activity associated with emotion reactivity and regulation in young adults with non-suicidal self-injury.BJPsych open · 2025Article
- Brain Activation During Suicide-Specific Cognition in Trauma-Exposed Veterans.Suicide & life-threatening behavior · 2025Article
- Magnetic resonance imaging of regional gray matter volume in persons who died by suicide.Molecular psychiatry · 2025Article
- Biomarkers of Suicidal Ideation in Depression: Insights From VMHC Analysis and Machine Learning.Neuropsychiatric disease and treatment · 2025Article
- Neural correlates of decision making and executive function in suicidal thoughts and behaviors.Frontiers in psychiatry · 2025Review
- Altered dynamic functional connectivity of nucleus accumbens subregions in major depressive disorder: the interactive effect of childhood trauma and diagnosis.Social cognitive and affective neuroscience · 2024Article
- Altered gray matter volume and functional connectivity in adolescent borderline personality disorder with non-suicidal self-injury behavior.European child & adolescent psychiatry · 2024Article
- Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls.Molecular psychiatry · 2024Article
- Functional connectivity density of different suicidal behaviors in adolescents with major depressive disorders.Frontiers in psychiatry · 2024Article
- Resting-state network analysis of suicide attempt history in the UK Biobank.Psychological medicine · 2023Article
- Aberrant connectivity in the right amygdala and right middle temporal gyrus before and after a suicide attempt: Examining markers of suicide risk.Journal of affective disorders · 2023Article
- Pre-treatment functional connectivity of the cingulate cortex predicts anti-suicidal effects of serial ketamine infusions.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Altered brain activities in suicidal subjects have been reported in a number of neuroimaging studies. However, the activity aberrances were inconsistent in previous investigations. Thus, we aimed to address activity abnormalities in suicidal individuals. Databases were searched to perform a meta-analysis of whole-brain functional MRI studies of suicidal individuals through January 14, 2020. Meta-analyses were conducted using Seed-based d Mapping software. Based on a meta-analysis of 17 studies comprising 381 suicidal individuals and 642 controls, we mainly found that increased activity in the bilateral superior temporal gyrus, left middle temporal gyrus, and bilateral middle occipital gyrus, along with decreased activity in the right putamen and left insula, were detected in suicidal individuals compared with nonsuicidal subjects. To reduce methodological heterogeneity between the included studies, subanalyses of behavioral domains were conducted, and the right superior temporal gyrus was found to increase in all subanalyses of domains. In subanalyses of suicidal attempters and ideators, suicide attempters displayed hyperactivation in the bilateral superior temporal gyrus and left middle temporal gyrus and blunted responses in the left insula relative to controls. Suicidal ideators demonstrated elevated activation in the right middle occipital gyrus and reduced activity in the right putamen relative to controls. The bilateral superior temporal gyrus was the most robust finding, replicable in all data sets in the jackknife sensitive analysis. Moreover, increased activity in the right superior temporal gyrus, left middle temporal gyrus, and right middle occipital gyrus was found to be involved with higher suicide ideation scores. This study revealed several brain regions associated with suicidality. These findings may contribute to our understanding of the pathophysiology of suicide and have important implications for suicide prevention and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.