ArticleJournal, genetic engineering & biotechnology2021
In vitro anticancer activity of ethanol extract of Adhatoda vasica Nees on human ovarian cancer cell lines.
Article in Journal, genetic engineering & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Mechanistic Exploration of the anticancer activity of Justicia adhatoda Plant Leaf Ethanolic Extract against Colon Cancer Cells: An in silico and in vitro Approach.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- The Multifaceted Potential ofMini reviews in medicinal chemistry · 2026Review
- Tibetan medicine Baxiaga: a systematic review of its historical herbalogical investigation, phytochemical constituents, and pharmacological activities.Frontiers in pharmacology · 2026Review
- Unveiling the anticancer potential of3 Biotech · 2024Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOvarian cancer causes more deaths than any other cancer of the female reproductive system because there is no effective screening and most women are diagnosed at advanced stages. The probability of survival at 5 years is less than 30%, and the limitation is that it will not respond to chemotherapy protocol and surgery as well. Moreover, some evidence have shown potential anticancer properties of flavonoids, protective chemicals in plant foods, such as being an antioxidant, antiestrogenic, antiproliferative, and antiinflammatory. In this study, the anticancer activity of crude ethanol extracts of leaves from Adhatoda vasica was investigated.
resultsBy the application of a cell-based assay, the LC 50 value of the A. vasica which showed anticancer effect was used for further studies. The cell line treated with LD 50 value of A. vasica extracts was observed for 0 h, 24 h, and 48 h to reveal the inhibition of the metastatic property in treated PA1 cells. The mRNA isolated from the teratocarcinoma PA1 cells treated with the A. vasica extract was further converted to cDNA and was amplified for the analysis of the p53 gene, p21 gene, and GAPDH gene expression. The expression in treated cells and the untreated control indicated the activity of the A. vasica extract against the ovarian cancer.
conclusionThe present study suggested the antiproliferative and antimetastatic effects of medicinal plant A. vasica on PA1 cells.
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