Evidence map›Paper›PMID 34351501›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2021

Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A.

Kristina Ritter, Jochen Behrends, Hanna Erdmann, Jasmin Rousseau, Alexandra Hölscher, Johanna Volz, Immo Prinz, Thomas Lindenstrøm, Christoph Hölscher

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Serum lymphocytes and cytokines: diagnostic value and influence on the immune status in patients with pulmonary tuberculosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023
    Article
  3. High-DoseCells · 2022
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kristina RitterInfection Immunology, Research Center Borstel, Borstel, Germany.
Jochen BehrendsFluorescence Cytometry Core Unit, Research Center Borstel, Borstel, Germany.
Hanna ErdmannInfection Immunology, Research Center Borstel, Borstel, Germany.
Jasmin RousseauInfection Immunology, Research Center Borstel, Borstel, Germany.
Alexandra HölscherInfection Immunology, Research Center Borstel, Borstel, Germany.
Johanna VolzInfection Immunology, Research Center Borstel, Borstel, Germany.
Immo PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Thomas LindenstrømDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Christoph HölscherInfection Immunology, Research Center Borstel, Borstel, Germany. choelscher@fz-borstel.de.ORCID 0000-0002-7520-9146
Research Center Borstel - Leibniz Lung Center · DEStatens Serum Institut · DKUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-17A-producing T helper (Th)17 cells are increasingly being acknowledged to be associated with protective immunity to Mycobacterium tuberculosis (Mtb). Subunit vaccines potently promote protective immune responses against Mtb infection that correlate with an expansion of IL-23-dependent Th17 cells. Previous studies revealed that after vaccination, IL-23 is required for protection against challenge with Mtb but the underlying IL-23-dependent-and possibly IL-17A-mediated-mechanisms remain elusive. Therefore, we here analyzed the early outcome of Mtb infection in C57BL/6, IL-23p19-deficient (

Indexed as

AnimalsAntigens, BacterialCD4-Positive T-LymphocytesFemaleInterleukin-17Interleukin-23MaleMiceMice, Inbred C57BLMice, KnockoutMycobacterium tuberculosisTuberculosisTuberculosis VaccinesVaccines, SubunitAntigens, BacterialInterleukin-17Interleukin-23Tuberculosis VaccinesVaccines, SubunitCytokinesMiceT cellsTuberculosisVaccination

Identifiers

PMID34351501
PMCPMC8541990
OpenAlexW3189879415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.