Evidence map›Paper›PMID 34351491›Full record

ArticleParasitology research2021

Leishmania infantum (syn. L. chagasi) parasites affect the release of soluble CD14 by infected macrophages.

Michelle Barreto Gomes Melo, Luana Celina Seraphim Cunha, Cárcia Santana Passos Barreto, Fabrícia Alvisi de Oliveira Mendonça, Micheli Luize Barbosa Santos, Danielle Sacramento, Amélia Ribeiro de Jesus, Roque Pacheco Almeida, Priscila Lima Dos Santos

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Microorganisms · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michelle Barreto Gomes MeloPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Luana Celina Seraphim CunhaPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Cárcia Santana Passos BarretoPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Fabrícia Alvisi de Oliveira MendonçaPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Micheli Luize Barbosa SantosPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Danielle SacramentoPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Amélia Ribeiro de JesusPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Roque Pacheco AlmeidaPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil.
Priscila Lima Dos SantosPrograma de Pós-Graduação Em Ciências da Saúde, Universidade Federal de Sergipe, 49060-100, Aracaju, Sergipe, Brasil. plimabio@gmail.com.
Universidade Federal de Sergipe · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 429246/2016-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 1071692
6 · The paper itself

Abstract

Functionally, cluster of differentiation 14 (CD14) is a co-receptor of the complex formed by lipopolysaccharide (LPS) and LPS-binding protein expressed on the membrane of a variety of cells. However, CD14 can be shed from the cell membrane into the circulation as soluble CD14 (sCD14) upon cell activation. Previously, our group reported that elevated sCD14 serum levels were associated with the clinical and laboratory findings in the context of visceral leishmaniasis (VL), but not in the context of LPS stimulation or bacterial infection. In the present study, we investigated the secretion dynamics of sCD14 in the context of Leishmania infantum (syn. L. chagasi) in vitro infection. Macrophages from treated VL patients and delayed-type hypersensitivity positive (DTH

Indexed as

Leishmania infantumAnimalsCell DifferentiationHumansLeishmaniasis, VisceralLipopolysaccharide ReceptorsMacrophagesLipopolysaccharide ReceptorsCD14LeishmaniaMacrophageVisceral leishmaniasis

Identifiers

PMID34351491
OpenAlexW3190099217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.