Evidence map›Paper›PMID 34351486›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Epithelioid leiomyosarcoma of broad ligament harboring PGR-NR4A3 and UBR5-PGR gene fusions: a unique case report.

Huayan Ren, Yimin Li, Qianlan Yao, Hong Lv, Shaoxian Tang, Xiaoyan Zhou, Wentao Yang

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Case Report: A case ofFrontiers in oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Huayan Ren *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0002-5194-7996
Yimin Li *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Qianlan YaoDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Hong LvDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Shaoxian TangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Xiaoyan ZhouDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Wentao YangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China. yangwt2000@163.com.
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel molecular subset of epithelioid leiomyosarcomas with rhabdoid features harboring PGR gene rearrangements has recently been documented. Herein, we present a unique case of PGR-rearranged smooth muscle tumor with both PGR-NR4A3 and UBR5-PGR gene fusions reported in a 30-year-old woman who had a mass in the broad ligament. The histological examination showed a round/polygonal to spindle cell tumor with abundant myxoid matrix and focal hyalinization, resulting in an epithelioid pattern. Immunohistochemical examination revealed that the tumor had variable staining for desmin, SMA, and h-caldesmon and diffuse nuclear staining of ER, PR, and WT1. Furthermore, targeted RNA sequencing analysis revealed PGR-NR4A3 and UBR5-PGR gene fusions. Our case in addition with the reported cases suggest that myxoid matrix with two types of tumor cells (round/polygonal epithelioid cells and spindle cells) may be significant for the diagnosis of PGR-NR4A3 fusion-positive leiomyosarcoma. UBR5-PGR gene fusion is a novel finding in epithelioid leiomyosarcoma.

Indexed as

Broad LigamentLeiomyosarcomaReceptors, SteroidSmooth Muscle TumorAdultBiomarkers, TumorDNA-Binding ProteinsFemaleGene FusionGene RearrangementHumansReceptors, Thyroid HormoneUbiquitin-Protein LigasesBiomarkers, TumorDNA-Binding ProteinsNR4A3 protein, humanReceptors, SteroidReceptors, Thyroid HormoneUbiquitin-Protein LigasesUBR5 protein, humanBroad ligamentEpithelioid leiomyosarcomaPGR-NR4A3UBR5-PGR

Identifiers

PMID34351486
OpenAlexW3193062122

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.