ArticleDevelopment (Cambridge, England)2021
QuantifyPolarity, a new tool-kit for measuring planar polarized protein distributions and cell properties in developing tissues.
Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis.Current biology : CB · 2026Article
- Dachsous-Fat signaling shapes the Drosophila wing through mechanical forces.PLoS biology · 2026Article
- Article
- Planar cell polarity emerges through polarized accumulation of Wnt11.Science advances · 2026Article
- Article
- Dying occurs as a defined molecular progression iniScience · 2025Article
- Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.Nature communications · 2025Article
- Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing.Nature communications · 2025Article
- The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis.Current biology : CB · 2025Article
- The tumour histopathology "glossary" for AI developers.PLoS computational biology · 2025Review
- Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding.Developmental cell · 2024Article
- Fat-Dachsous planar polarity function requires two distinct heterophilic cadherin-cadherin binding interactions.Cell reports · 2024Article
- PCP Auto Count: A Novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.bioRxiv : the preprint server for biology · 2024Article
- PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.Frontiers in cell and developmental biology · 2024Article
- Evaluating Planar Cell Polarity in the Developing Mouse Epidermis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway.Current biology : CB · 2023Article
- Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.Development (Cambridge, England) · 2023Article
- Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging theMolecular biology of the cell · 2023Article
- An ImageJ-based tool for three-dimensional registration between different types of microscopic images.Development, growth & differentiation · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The coordination of cells or structures within the plane of a tissue is known as planar polarization. It is often governed by the asymmetric distribution of planar polarity proteins within cells. A number of quantitative methods have been developed to provide a readout of planar polarized protein distributions. However, previous planar polarity quantification methods can be affected by variation in cell geometry. Hence, we developed a novel planar polarity quantification method based on Principal Component Analysis (PCA) that is shape insensitive. Here, we compare this method with other state-of-the-art methods on simulated models and biological datasets. We found that the PCA method performs robustly in quantifying planar polarity independently of variation in cell geometry and other image conditions. We designed a user-friendly graphical user interface called QuantifyPolarity, equipped with three polarity methods for automated quantification of polarity. QuantifyPolarity also provides tools to quantify cell morphology and packing geometry, allowing the relationship of these characteristics to planar polarization to be investigated. This tool enables experimentalists with no prior computational expertise to perform high-throughput cell polarity and shape analysis automatically and efficiently.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.